SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.

Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells and the viral lineage.

The importance of objectively measuring functional tests in complement to self-report assessments in patients with knee osteoarthritis.

Background: Osteoarthritis (OA) is a chronic degenerative disease which can result in chronic pain, loss of joint function and consequently decline in quality of life.

Research Question: A variety of instruments that measure the different dimensions of health status in patients with OA are available. However, despite the fact that WOMAC and other questionnaires and scales may provide additional understanding regarding the patient's condition, some studies have reported discrepancies between patients' perceptions and their actual ability to perform the task.

Venous thromboembolism in childhood: where is Brazil after 20 years?

Due to the longer survival of critically ill children, venous thromboembolism is a problem which is becoming increasingly recognized in pediatric practice. In the last decades, several international studies have been published, shedding a light upon the epidemiology of this disease during childhood. These data show peculiarities in the clinical presentation and the significant morbidity and mortality.

Effect of the injectable contraceptive depot-medroxyprogesterone acetate on coagulation parameters in new users.

Aim: The aim of this study was to assess the effects of the injectable depot-medroxyprogesterone acetate (DMPA) contraceptive on selected blood coagulation parameters in young, healthy new users.

Methods: The prospective study included 39 healthy women aged 20-39 years, with a body mass index (BMI; kg/m ) < 30, who were never users of DMPA, and who opted to use DMPA (21 women) or a copper intrauterine device (IUD; 18 women). The women in the two groups were matched for age (±1 year) and BMI (±1).

Increased intraoperative bleeding in patients undergoing abdominoplasty after gastroplasty is not due to coagulopathy.

Background: Abdominoplasties carried out in patients previously underwent gastroplasty present high rates of complications, including increased bleeding in the intra- and postoperative periods.

Methods: This study evaluated bleeding, coagulation parameters (coagulogram, dosage of fibrinogen, FII, FV, FVII, FVIII, FIX, FX, and FXII), and thromboelastography in two groups of women who underwent abdominoplasties: a group with a history of gastroplasty by the Fobi-Capella technique (group I) and the other group without a history of obesity (group II). Analyses were performed before, during, and after each surgical procedure.

Possible association between cytomegalovirus infection and gastrointestinal bleeding in hemophiliac patients.

Cytomegalovirus (CMV) infection is of major concern in immunocompromised and immunosuppressed patients. Prior to the introduction of HIV-1 antibody screening and efficient virucidal processes to inactivate viruses, individuals with a factor VIII or factor IX deficiency had a high risk of contracting HIV-1 infection through the infusion of contaminated blood products. In addition, blood products were also frequently associated with alterations in immune function.

[Spontaneous epidural hematoma. Report of two cases].

Spontaneous epidural hematomas are rarely described in literature. They are associated with infectious diseases of the skull, coagulation disorders, vascular malformations of the dura-mater and metastasis to the skull. The authors report two cases of spontaneous epidural hematoma of different etiologies, and study parameters of hemostasis.

Immunoglobulin levels in workers exposed to inorganic mercury.

The serum immunoglobulin (IgG, IgM and IgA) concentrations of 44 mercury-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had a mean (+/- S.D.

[Use of autologous fibrin glue in facial reconstruction by total skin graft].

Fibrin glue of human origin was used in 12 patients following excision of facial skin tumors and reconstruction skin graft. Positive results were achieved in all cases with good by full-thickness healing, reduction of operating time and good aesthetic results.

Hairy cell leukemia and multiple autoimmune manifestations in a human immunodeficiency virus-infected patient.

Aggressive B-cell lymphomas are clearly related to HIV infection. However, the relationship of HIV infection to low-grade B- or T-cell lymphomas and Hodgkin's disease is not well established. The authors describe a case in which hairy cell leukemia was associated with lupus anticoagulant and direct Coombs' test in an HIV-positive patient.