extract induces apoptosis and pyroptosis via caspase-3/PARP/GSDME pathways in A549 cell line.

(CM) is traditionally used as dietary therapy for lung cancer patients in China. CM extract (CME) is hydrosoluble fraction of CM and extensively investigated. Caspase-3-involved cell death is considered as its major anticancer mechanism but inconclusive.

Primary Resistance to Brigatinib in a Patient with Lung Adenocarcinoma Harboring G1202R Mutation and Rearrangement.

Purpose: Anaplastic lymphoma kinase () inhibitors have transformed the management of non-small-cell lung cancer (NSCLC) patients with gene rearrangement. This paper reports a new resistance mechanism to a second-generation ALK inhibitor, brigatinib.

Case Report: A 43-year-old woman who had no history of smoking was diagnosed with stage IVa (T2bN2M1b) lung adenocarcinoma.