Differential diagnosis and clinical management of isolated prolonged activated partial thromboplastin time in a patient with Hashimoto thyroiditis-associated thyroid cancer: A case report.

Rationale: Patients preparing for surgery may have isolated, prolonged activated partial thromboplastin time (APTT). Cause analysis is warranted in patients who had neither bleeding symptom nor thromboembolic events because isolated prolongation of APTT may lead to unnecessary delayed surgical intervention or invasive procedure, even ineffective plasma infusion treatments. Here, we report a case of Hashimoto thyroiditis-associated thyroid cancer whose APTT was isolated prolonged and discuss the challenges of diagnosis and clinical management of this patient.

Phenotypic Variation and Carbapenem Resistance Potential in OXA-499-Producing .

is increasingly recognized as a clinically important species. Here, we identified a carbapenem-non-resistant clinical isolate, A1254, harboring , , and . The genetic environment in A1254 was identical to that of another OXA-499-producing, but carbapenem-resistant, isolate, YMC2010/8/T346, indicating the existence of phenotypic variation among OXA-499-producing strains.

Dual Role of in Antibiotic Resistance and Virulence in Acinetobacter baumannii.

is an important Gram-negative pathogen in hospital-related infections. However, treatment options for infections have become limited due to multidrug resistance. Bacterial virulence is often associated with capsule genes found in the K locus, many of which are essential for biosynthesis of the bacterial envelope.