Simultaneous Fabrication of P and M Helices in One-Component Chiral System by Methanol-Water Mediated Dual Assembly Pathway.

The synergetic evolution of multiple chiral structures stemmed from same building units is ubiquitous in nature and vital to living systems, but achieving it in artificial systems remains a challenge. Herein, we report a methanol-water mediated dual assembly pathway strategy for simultaneous construction of P and M helices in one-component chiral system. The conformation of l-phenylaniline derivates (LBpyF) is controlled to folded state in CHOH due to the hydrogen bonds as well as C-H⋅⋅⋅π interaction between LBpyF and CHOH.

Succinylation of 14-3-3 theta by CPT1A promotes survival and paclitaxel resistance in nasal type extranodal natural killer/T-cell lymphoma.

Background: The aggressive and refractory extranodal natural killer/T-cell lymphoma, nasal type (ENKTL-NT) is a subtype of non-Hodgkin's lymphoma. Succinylation promotes progression in a variety of tumors, but its mechanism in ENKTL-NT is unclear.

Methods: Bioinformatic analysis was performed to screen differentially expressed genes in the ENKTL dataset.

A dynamic assembly-induced emissive system for advanced information encryption with time-dependent security.

The development of advanced materials for information encryption with time-dependent features is essential to meet the increasing demand on encryption security. Herein, smart materials with orthogonal and temporal encryption properties are successfully developed based on a dynamic assembly-induced multicolour supramolecular system. Multicolour fluorescence, including blue, orange and even white light emissions, is achieved by controlling the supramolecular assembly of pyrene derivatives by tailoring the solvent composition.