Publications by authors named "Bixue Chen"

Positive computed tomography (CT) contrast nanoagent has significant applications in diagnosing tumors. However, the sensitive differentiation between hepatoma and normal liver tissue remains challenging. This challenge arises primarily because both normal liver and hepatoma tissues capture the nanoagent, resulting in similar positive CT contrasts.

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Objectives: Aimed to investigate whether there are abnormal changes in the functional connectivity (FC) between the amygdala with other brain areas, in Parkinson's disease (PD) patients with anxiety.

Methods: Participants were enrolled prospectively, and the Hamilton Anxiety Rating (HAMA) Scale was used to quantify anxiety disorder. Rest-state functional MRI (rs-fMRI) was applied to analyze the amygdala FC patterns among anxious PD patients, non-anxious PD patients, and healthy controls.

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Different subtypes of breast cancer (BCC) have variable degrees of malignancy, which is closely related to their extracellular pH (pH). Therefore, it is increasingly significant to monitor the extracellular pH sensitively to further determine the malignancy of different subtypes of BCC. Here, a l-arginine and Eu assembled nanoparticle Eu@l-Arg was prepared to detect the pH of two breast cancer models (TUBO is non-invasive and 4T1 is malignant) using a clinical chemical exchange saturation shift imaging technique.

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Purpose: To develop and validate a new nomogram utilizing non-contrast computed tomography (NCCT) signs and clinical factors for predicting hematoma expansion (HE) in patients with spontaneous intracerebral hemorrhage (ICH).

Methods: HE was defined as > 6 mL or 33% increase in baseline hematoma volume. Multivariable logistic regression analysis was performed to identify the predictors of HE.

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Synopsis of recent research by authors named "Bixue Chen"

  • - Bixue Chen's research primarily focuses on advanced imaging techniques and nanotechnology applications in the medical field, specifically targeting tumor detection and brain connectivity issues associated with neurological disorders.
  • - Recent studies include the development of novel contrast nanoagents for enhanced sensitivity in distinguishing hepatoma from normal liver tissue and for differentiating malignancy levels in breast cancer subtypes based on extracellular pH.
  • - Chen's work also explores the functional connectivity changes in the brain's fear circuit in Parkinson's disease patients with anxiety, employing advanced imaging methodologies such as rest-state functional MRI to reveal significant neural alterations.

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