The Bioaccumulation and Biodegradation of Testosterone by .

In the present study, the accumulation and degradation of testosterone by were studied. The results showed that C. has a significant ability to eliminate testosterone by bioaccumulation and biodegradation, and during the 96 h experimental period, the data demonstrated that the accumulation of testosterone followed a sigmoidal accumulation pattern.

TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells.

Background/aims: Osteosarcoma (OS) is a primary malignant bone tumor in humans, and is notorious mainly for its distal metastases. We have recently shown that Shikonin, an effective constituent extracted from Chinese medicinal herb, inhibits OS cell invasion through suppression of matrix metalloproteinase 13 (MMP13). However, the underlying mechanisms remain unknown.