Parents' Perceptions of Children's Behavioral Difficulties and the Parent-Child Interaction During the COVID-19 Lockdown.

The study examined parents' perceptions of their children's behavioral difficulties (CBD) and positive parent-child interaction (PCI) during the first COVID-19 lockdown in Israel, as well as the associations among parents' psychological distress, parents' COVID-19-related worries, parents' coping, and parents' resilience. Participants were 437 parents of minor children. Parents reported more behavioral and emotional difficulties alongside with more quality time with their children.

Estimation of model accuracy by a unique set of features and tree-based regressor.

Computationally generated models of protein structures bridge the gap between the practically negligible price tag of sequencing and the high cost of experimental structure determination. By providing a low-cost (and often free) partial alternative to experimentally determined structures, these models help biologists design and interpret their experiments. Obviously, the more accurate the models the more useful they are.

Nurse Prompting for Prescriber-Led Review of Antimicrobial Use in the Critical Care Unit.

Background: Developing a sustainable strategy for prescriber-led review of antimicrobial use in a critical care unit may improve antimicrobial use without the need for additional resources.

Methods: Using a quality improvement framework, the researchers created a prompt for prescriber-led review of antimicrobial use. The outcome measure was antimicrobial use (days of therapy per 1000 patient days).

[Residual symptoms after a treated major depressive disorder: a survey among private psychiatrists].

Unlabelled: Recent studies suggest that depression with residual symptoms is a frequent progressive form of this disease. It is associated with a poor prognosis that translates into an earlier and higher relapse rate, and has a significant medical and social impact. Several literature reviews emphasize that residual symptoms are under-evaluated and that their treatment should follow an incisive strategy with the goal of complete eradication of symptoms.

[Anaphylactic shock after traumatic rupture of a splenic echinococcal cyst].

Anaphylactic shock as a result of trauma is very rare. We describe a 20-year-old Druze soldier who presented with anaphylactic shock due to rupture of a splenic echinococcal cyst induced by blunt trauma to the left chest wall and upper abdomen. The main clinical manifestations, which developed within minutes of the trauma, were high fever, pruritus, edema of the lips and eyelids, dyspnea, stridor and rhinorrhea.

Structural changes in fibrin clot associated with the proteolytic activity induced by tissue type plasminogen activator. An NMR study.

The kinetic behavior of fibrin clot lysis as induced by tissue-type plasminogen activator (t-PA) was studied using proton magnetic resonance (PMR) and a release assay of fibrin labeled with technetium-99m isotope (99mTc). The lysis pattern of the preformed clot was examined as a function of gradual changes in the amounts of added t-PA and deactivated t-PA. The behavior of fibrinolysis was found to depend strongly on the amount of t-PA in the assay, which markedly affects the lysis rate of fibrin.

Clot uptake of labeled active and inhibited tissue plasminogen activator.

The clot uptake of labeled active and inhibited t-PA was compared. The most efficient inhibition was obtained with diisopropyl fluorophosphate (DFP) after 4 h incubation at room temperature. Enzyme activity was followed by fibrin-plate assay, radioactivity-release technique and proton magnetic resonance (PMR).

Labeling of sarcoma associated monoclonal antibody with 111In, 67Ga and 125I.

Labeling of human sarcoma-associated murine monoclonal antibody (MAb) 23H7 with 67Ga and 111In by the bifunctional ligand method is reported. 67Ga was chelated to the MAb via desferrioxamine B and 111In via the cyclic anhydride of DTPA. Higher specific activity was obtained with 67Ga (4-5 microCi/micrograms) as compared with 111In (2 microCi/micrograms).

Human sarcoma-associated murine monoclonal antibody labeled with indium-111, gallium-67, and iodine-125.

Monoclonal antibody (MAb) 23H7 is a hybridoma-derived IgG that is generated following fusion of mouse myeloma cell line P3U1 and spleen cells from BALB/c mice hyperimmunized with a human fibrosarcoma. It detects a mesenchymal antigen of 23KD expressed on human sarcoma tissues and other neoplasms, including myeloid leukemias, but it rarely binds to normal tissues. The MAb 23H7 was labeled with 67Ga and 111In using the bifunctional ligand method.

Factors affecting the labeling of human fibrinogen with 99mTc in vitro.

The preparation of [99mTc]fibrinogen is described. The following factors which could affect the quality of this preparation were studied: pH, SnCl2 and protein concentrations, pre- and post-labeling incubation times and labeling temperature. A 90% labeling yield was achieved by incubating fibrinogen with SnCl2 at pH 9.

Modified human fibrinogen labeled with 111In.

A method for the labeling of human fibrinogen with 111In is reported. The cyclic anhydride of DTPA, either dissolved in dimethyl sulfoxide or as the solid, is first covalently attached to the protein. The modified fibrinogen is then labeled with [111In]acetate, with an average yield of 90 +/- 3%.