Breast cancer and cervical cancer: a comparison of the period before and during the COVID-19 pandemic.

Background: The coronavirus 2019 (COVID-19) pandemic impacted cancer health care in several countries, with delays in the detection and treatment of breast and cervical cancer. The objective of this study is to analyze and compare the screening, diagnosis and treatment of breast and cervical cancer in the pre-COVID period and during the COVID-19 period.

Methods: Cross-sectional study with secondary data collected from the Mortality Information System (SIM), Hospital Information System (SIH), Ambulatory Information System (SIA) and the Oncology Panel (PO) of breast cancer notifications with ICD C50.

Confronting mobile phone signal coverage and helicopter emergency medical service travel time: A geospatial analysis in the northwest macro-region of Paraná State, Brazil.

Objective: The aim of this study was to conduct a detailed geospatial analysis of mobile phone signal coverage in the northwest macro-region of Paraná State, Brazil, seeking to identify areas where limitations in coverage may be related to lengthy travel times of the helicopter emergency medical service (HEMS) for the assistance of victims of road traffic injuries (RTIs).

Methods: An observational study was conducted to examine mobile phone signal coverage and HEMS travel times from 2017 to 2021. HEMS travel times were categorized into four groups: T1 (0-15 min), T2 (16-30 min), T3 (31-45 min), and T4 (over 45 min).

Designing, development and validation of an app to reduce the response time of the emergency medical services.

Introduction: Delays in prehospital care attributable to the call-taking process can often be traced back to miscommunication, including uncertainty around the call location. Geolocation applications have the potential to streamline the call-taking process by accurately identifying the caller's location.

Objective: To develop and validate an application to geolocate emergency calls and compare the response time of calls made via the application with those of conventional calls made to the Brazilian Medical Emergency System (Serviço de Atendimento Médico de Urgência-SAMU).

A look through Latin America truck drivers' health, a systematic review and meta-analysis.

Heavy truck drivers represent a social group of great importance to any country's economy. Their professional activity requires a high level of dedication. Due to the irregular hours in their work routine and adopted habits, they mostly predispose them to a diversity of health problems.

Oblique line contrast: A new radiomorphometric index for assessing bone quality in dental panoramic radiographs.

Unlabelled: The present study was carried out to assess the possible changes in mandibular bone density according to age and gender through dental panoramic radiographs (PAN). More specifically, the region of the mandibular oblique line.

Materials & Methods: A group of 374 dental patients previously treated in the Ribeirão Preto Dental School (FORP/USP) was included in the study.

Prevalence and Impact of Academic Violence in Medical Education.

Situations of mistreatment in the academic environment are prevalent worldwide, but research in this area is scarce in middle-low-income countries. This study aimed to estimate the prevalence of mistreatment inflicted against Brazilian medical students. In addition, characterize these situations and analyze their consequences.

Ecotoxicology and geostatistical techniques employed in subtropical reservoirs sediments after decades of copper sulfate application.

Spatial distribution linked to geostatistical techniques contributes to sum up information into an easier-to-comprehend knowledge. This study compares copper spatial distribution in surface sediments and subsequent categorization according to its toxicological potential in two reservoirs, Rio Grande (RG) and Itupararanga (ITU) (São Paulo-Brazil), where copper sulfate is applied and not applied, respectively. Sediments from 47 sites in RG and 52 sites in ITU were collected, and then, copper concentrations were interpolated using geostatistical techniques (kriging).

Central adrenal insufficiency: who, when, and how? From the evidence to the controversies - an exploratory review.

Central adrenal insufficiency (CAI) is a life-threatening disorder. This occurs when ACTH production is insufficient, leading to low cortisol levels. Since corticosteroids are crucial to many metabolic responses under organic stress and inflammatory conditions, CAI recognition and prompt treatment are vital.

Air Medical Transportation Provided by Norte Novo Regional Urgency Mobile Service: What Is the Current Scenario?

Objective: The aim of this study was to investigate, describe, and analyze the Norte Novo regional air medical service provided by the Brazilian Emergency Medical Rescue Service.

Methods: This was a retrospective and descriptive study with a quantitative approach of the incidents registered from November 2016 to December 2019. For general patient classification, descriptive statistics of the following variables were performed: sex, age/age group, type of diagnosis, city where the incident took place, city of destination, length of patient care, ventilatory support, use of sedation, and use of vasoactive drugs.

The Impact of Violence on the Anxiety Levels of Healthcare Personnel During the COVID-19 Pandemic.

The COVID-19 pandemic stressed the importance of healthcare personnel. However, there is evidence of an increase in violence against them, which brings consequences, such as anxiety. The aim of this study was to analyze the anxiety levels of health professionals who have or not suffered violence during the COVID-19 pandemic, and verify the variables associated with the risk of starting to take medication for anxiety.

Analysis of baseline characteristics, disease burden and long-term follow-up of 167 patients with Paroxysmal Nocturnal Hemoglobinuria at a single center in Brazil.

Unlabelled: Paroxysmal nocturnal hemoglobinuria (PNH) can occur as a hemolytic form or small PNH clone found in a patient with bone marrow failure.

Methods: Describe Brazilian retrospective PNH cohort and identify the impact of disease burden on long-term follow-up.

Results: 167 patients, mean age at diagnosis 28.

Helicopter Transportation of Brazilian Trauma Patients: A Comparison of Times to Care.

Objective: The purpose of this study was to analyze helicopter emergency medical service (HEMS) transport with secondary land ambulance transfer, comparing landings performed inside and outside the hospital complex to the emergency department.

Methods: This was a cross-sectional observational study of HEMS transports of trauma patients between 2016 and 2018 in southern Brazil. Patients were attended by the HEMS team at the trauma site or stabilized in hospitals nearby and subsequently referred to trauma centers.

Predictors of violence against health professionals during the COVID-19 pandemic in Brazil: A cross-sectional study.

Background: The increase in violence against health professionals in the COVID-19 pandemic makes it necessary to identify the predictors of violence, in order to prevent these events from happening.

Objective: Evaluating the prevalence and analyzing the variables involved in the occurrence of violence against health professionals during the COVID-19 pandemic in Brazil.

Method: This is a cross-sectional study conducted online involving Brazilian health professionals during the COVID-19 pandemic.

Water quality assessment using Sentinel-2 imagery with estimates of chlorophyll a, Secchi disk depth, and Cyanobacteria cell number: the Cantareira System reservoirs (São Paulo, Brazil).

Satellite images were used to assess surface water quality based on the concentration of chlorophyll a (chla), light penetration measured by the Secchi disk method (SD), and the Cyanobacteria cells number per mL (cyano). For this case study, six reservoirs interconnected were evaluated, comprising the Cantareira System (CS) in São Paulo State (Brazil). The work employed Sentinel-2 images from 2015 to 2018, SNAP image processing software, and the native products conc_chl and kd_z90max, treated using Case 2 Regional Coast Color (C2RCC) atmospheric correction.

Metabolomics as a potential tool for the diagnosis of growth hormone deficiency (GHD): a review.

Metabolomics uses several analytical tools to identify the chemical diversity of metabolites present in organisms. These metabolites are low molecular weight molecules (<1500 Da) classified as a final or intermediary product of metabolic processes. The application of this omics technology has become prominent in inferring physiological conditions through reporting on the phenotypic state; therefore, the introduction of metabolomics into clinical studies has been growing in recent years due to its efficiency in discriminating pathophysiological states.

Buclizine crystal forms: First Structural Determinations, counter-ion stoichiometry, hydration, and physicochemical properties of pharmaceutical relevance.

Buclizine (BCZ) is a chiral synthetic piperazine derivative which has antihistaminic, anti-muscarinic and antiemetic properties, and has been reintroduced as an appetite stimulant, especially for pediatric patients. Structural information about this drug, as well as other buclizine crystalline forms (solvates, salts and co-crystals) including the BCZ free-base (BCZ-FB), is non-existent. Here, we present for the first time the crystal structure of the monohydrochloride monohydrate salt of BCZ (BCZHCl·HO), and of its anhydrous form, BCZHCl.

VARIABLES INVOLVED IN THE MANAGEMENT OF SCHOOL BULLYING: A BAYESIAN NETWORK ANALYSIS.

Objective: To analyze the management of bullying by the managers of elementary schools.

Methods: Descriptive, exploratory research carried out through semi-structured interviews with 17 school counselors from a city in the South of Brazil, randomly selected from different geographical sectors. The interviews were recorded with participants' consent and, after transcription and checking, were discarded.

Age and calving time affects production efficiency of beef cows and their calves.

The aim of this study was to evaluate the influence of two sub-periods of the calving season and two cow maturity stages on the efficiency of beef cows and their calves. A total of 159 cow-calf pairs were divided by calving time (early or late) within the calving season and maturity stage (young or adult). Calves were weaned at 42 or 63 days after birth and evaluated until 210 days of age.

Protective effect of aqueous extract, fractions and phenolic compounds of Hancornia speciosa fruits on the inflammatory damage in the lungs of mice induced by Tityus serrulatus envenomation.

Scorpion envenomation has been considered a public health issue around the world. Tityus serrulatus represents a specie of major medical importance in Brazil due to mortality rates of approximately 1% among children and elderly populations. The aim of this work was to evaluate the in vivo anti-inflammatory potential of aqueous extract from Hancornia speciosa fruits, its fractions and its phenolic compounds against T.

Late chimerical status after bone marrow transplantation in severe aplastic anemia according to two different preparatory regimens.

Background: This study investigated the influence of two conditioning regimens on the chimerical status of 104 patients with acquired severe aplastic anemia.

Methods: Patients were monitored for at least 18 months after related bone marrow transplantation and reaching partial or complete hematologic recovery. Group I patients ( = 55) received 200 mg/kg cyclophosphamide alone and Group II ( = 49) received 120 mg/kg cyclophosphamide associated with 12 mg/kg busulfan.

Wall function treatment for bubbly boundary layers at low void fractions.

The present work investigates the role of different treatments of the lower boundary condition on the numerical prediction of bubbly flows. Two different wall function formulations are tested against experimental data obtained for bubbly boundary layers: (i) a new analytical solution derived through asymptotic techniques and (ii) the previous formulation of Troshko and Hassan (IJHMT, 44, 871-875, 2001a). A modified k-e model is used to close the averaged Navier-Stokes equations together with the hypothesis that turbulence can be modelled by a linear superposition of bubble and shear induced eddy viscosities.

Impact of copper sulfate application at an urban Brazilian reservoir: A geostatistical and ecotoxicological approach.

A landscape ecotoxicology approach was used to assess the spatial distribution of copper in the recent bottom sediment (surficial sediment) of a Brazilian subtropical reservoir (the Guarapiranga reservoir) and its potential ecotoxicological impacts on the reservoir ecosystem and the local society. We discuss the policies and procedures that have been employed for the management of this reservoir over the past four decades. Spatial heterogeneity in the reservoir was evaluated by means of sampling design and statistical analysis based on kriging spatial interpolation.

A strategy for molecular diagnostics of Fanconi anemia in Brazilian patients.

Background: Fanconi anemia (FA) is a predominantly autosomal recessive disease with wide genetic heterogeneity resulting from mutations in several DNA repair pathway genes. To date, 21 genetic subtypes have been identified. We aimed to identify the FA genetic subtypes in the Brazilian population and to develop a strategy for molecular diagnosis applicable to routine clinical use.