Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population.

Background: Currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. The purpose of this study was to evaluate the value of serological parameters including serum pepsinogen I (PGI), pepsinogen II (PGII) and pepsinogen I: II ratio for the screening atrophic gastritis and gastric cancer.

Methods: The study population consisted of 132 dyspeptic patients who had undergone upper endoscopy with biopsy.