Non-Stoichiometric Amorphous Calcium Carbonate Forms in Macromolecular Condensates via Interphase Diffusion.

Transient amorphous phases are known as functional precursors in the formation of crystalline materials, both in vivo and in vitro. A common route to regulate amorphous calcium carbonate (ACC) crystallization is via direct interactions with negatively charged macromolecules. However, a less explored phenomenon that can influence such systems is the electrostatically driven formation of Ca-macromolecule dense phases.

Cordycepin and Its Structural Derivatives Effectively Suppress the High Expression of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase in Breast Carcinomas: A Computational Drug Development Approach.

Background: Breast cancer is a frequently diagnosed malignant disease and the primary cause of mortality among women with cancer worldwide. The therapy options are influenced by the molecular subtype due to the intricate nature of the condition, which consists of various subtypes. By focusing on the activation of receptors, Epidermal Growth Factor Receptor (EGFR) tyrosine kinase can be utilized as an effective drug target for therapeutic purposes of breast cancer.

Association of sleep duration and all-cause and cancer-specific mortality: results of 2004 national health interview survey (NHIS).

Epidemiologic research has demonstrated a connection between the duration of sleep and the risk of overall mortality. This research investigates the correlation between sleep duration (SD) and the likelihood of all-cause and cancer-specific mortality among cancer patients, exploring the association between SD and mortality risk. The study used the National Health Interview Survey (NHIS) data from 2004, a U.

Prevalence of chronic kidney disease and anemia in Hirakud Command Area, Odisha, India: unveiling the role of environmental toxicants.

Background: The present community-based study assessed the prevalence of chronic kidney disease (CKD)/chronic kidney disease of unknown origin (CKDu) as well as anemia in some intense agricultural zones under Hirakud Command Area and evaluated their association with pesticides and heavy metal exposure.

Methods: Random cluster sampling method was used to assess the prevalence of CKD and anemia. Hematological analysis was carried out using autoanalyzer.

Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina.

Most genetic risk variants linked to ocular diseases are non-protein coding and presumably contribute to disease through dysregulation of gene expression, however, deeper understanding of their mechanisms of action has been impeded by an incomplete annotation of the transcriptional regulatory elements across different retinal cell types. To address this knowledge gap, we carried out single-cell multiomics assays to investigate gene expression, chromatin accessibility, DNA methylome and 3D chromatin architecture in human retina, macula, and retinal pigment epithelium (RPE)/choroid. We identified 420,824 unique candidate regulatory elements and characterized their chromatin states in 23 sub-classes of retinal cells.

The survival of B cells is compromised in kidney disease.

Antibody-mediated protection against pathogens is crucial to a healthy life. However, the recent SARS-CoV-2 pandemic has shown that pre-existing comorbid conditions including kidney disease account for compromised humoral immunity to infections. Individuals with kidney disease are not only susceptible to infections but also exhibit poor vaccine-induced antibody response.

A robust MPPT framework based on GWO-ANFIS controller for grid-tied EV charging stations.

As electric vehicles gain popularity, there has been a lot of interest in supporting their continued development with the aim of enhancing their dependability, environmental advantages, and charging efficiency. The scheduling of navigation and charging for electric vehicles is among the most well-known research topics. For optimal navigation and charging scheduling, the coupled network state between the transportation and power networks must be met; moreover, the scheduling outcomes might significantly impact these networks.

Time-Reversal Symmetry Breaking Superconductivity in HfRhGe: A Noncentrosymmetric Weyl Semimetal.

Weyl semimetals are a novel class of topological materials with unique electronic structures and distinct properties. HfRhGe stands out as a noncentrosymmetric Weyl semimetal with unconventional superconducting characteristics. Using muon-spin rotation and relaxation (µSR) spectroscopy and thermodynamic measurements, a fully gapped superconducting state is identified in HfRhGe that breaks time-reversal symmetry at the superconducting transition.

Efficacy of Arogya Rakshak Panchatantra (Five Lifestyle Principles) on Heart Rate Variability and Menstrual Symptoms in Primary Dysmenorrhea: A Randomized Controlled Trial.

Primary dysmenorrhea (PD) is associated with decreased performance and reduced quality of life in young adults. This study aims to evaluate the effectiveness of implementing Arogya Rakshak Panchatantra (ARP), a naturopathic lifestyle practice, among young female adults with PD. This open-label, parallel-arm, randomized controlled trial included 52 young female adults with PD aged between 16 and 25 years.

Biochemical Alterations and Motor Dysfunctions in Corpus Striatum of Rats Brain Exposed to Azo Dyes.

Azo food dyes are prohibited in most countries, but their injudicious use is still reported particularly in the developing Nations. Continuous use of contaminated food raises health concerns and given this the present study designed to investigate the effects of 3 non-permitted azo dyes (metanil yellow - MY, malachite green - MG, and sudan III - SIII) on neurobehavioral, neurochemicals, mitochondrial dysfunction, oxidative stress, and histopathological changes in the corpus striatum of rats. Rats were grouped and treated with MY (430 mg/kg), MG (13.

Rheology of Ring Copolymers in Dilute Solutions.

We investigate the rheology of ring copolymers theoretically within the framework of the optimized Rouse-Zimm theory in dilute solutions. The ring copolymer is composed of two type of monomers (A and B) of different sizes (A < B), which is represented by unequal-sized beads connected via harmonic springs with different spring constants. The hydrodynamic interactions (HI) between the monomers is modeled using the preaveraged HI tensor.

C(sp)-H Acylation of Benzo[h]quinolines at Room Temperature via Aldehyde Autoxidation and Palladium Catalysis Cooperation.

Herein, we report Pd-catalyzed C(sp)-H acylation using aldehyde as acyl source and O as the green oxidant at room temperature. A selective association of acyl radical formed in-situ during aldehyde autoxidation with Pd-catalysis is the key to the process. The reaction afforded products in good yields (up to 82 %) and it is scalable.

Comparative analysis of selected plastic pyrolysis and catalytic versus non-catalytic pyrolysis of polyethylene using artificial neural networks for oil production.

Research on plastic pollution is crucial, particularly with the recent emphasis on converting waste plastics into oil for sustainable energy. Very few studies have utilized artificial neural network (ANN) modeling for plastic thermal conversion, such as predicting fuel yield from mixed plastics and performing sensitivity analyses to identify which plastics produce more oil. Meanwhile, no study has conducted a comparative analysis of different models for catalytic and non-catalytic thermal conversion of various plastics, nor has a sensitivity analysis of process parameters using ANN for oil production.

A Unique Case of Candida auris Infection Presenting With Hydropneumothorax and Bronchopleural Fistula: A Diagnostic and Therapeutic Challenge.

 is an emerging multidrug-resistant fungal pathogen that has become a significant global health concern, particularly in critically ill patients within hospital settings. It is known for its high mortality rates, diagnostic challenges, and frequent misidentification, which delays appropriate treatment. We present a case of a 72-year-old male with diabetes and hypertension who initially presented with a persistent cough, hemoptysis, and fever and was initially suspected of having pulmonary tuberculosis.

Effect of vegetable oil on ovarian steroidogenesis- A transcriptome approach to understand molecular mechanisms of hypothalamus pituitary and gonad axis (HPG) in Ompok bimaculatus.

Ompok bimaculatus is a commercially important food fish of Northeast India. For higher production of this species, the molecular mechanisms underlying its reproductive physiology is an important aspect to study. Vegetable oils are rich in ω3 and ω6 fatty acids and fat-soluble vitamins, that enhance reproductive performances.

Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank.

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, RCSB.org), the US Worldwide Protein Data Bank (wwPDB, wwPDB.org) data center for the global PDB archive, provides access to the PDB data via its RCSB.

Metal-Organic Framework-Templated Synthesis of Nickel-Alumina Nanocatalysts Improves Catalyst-Support Interaction for Higher Activity and Stability in Biogas Reforming under Controlled Oxidizing Conditions.

Tri-reforming methane with CO, O, and HO mixtures requires a delicate balance of dry-reforming, partial oxidation, and steam-reforming reactions to improve the CO conversion and H/CO ratio. Nickel-alumina has been reported before for the tri-reforming of methane, although at higher temperatures (>900 °C). This is because the current approaches for nickel-alumina synthesis are ineffective in generating stronger catalyst-support interactions necessary to maintain higher active sites and stall carbon nanotube (CNT) deposition.

Effects of Vitamin C on Growth and Non-Specific Immune Response of Fry in Density-Dependent Biofloc Rearing.

Biofloc technology offers a viable choice for the rearing of fish seed by offering a safe and protected habitat for young fish. Nevertheless, it is crucial to establish a standardised stocking density and implement effective ameliorative steps in order to successfully utilise this technology. In this study, a 90-day investigation was conducted to assess the effect of stocking density and dietary vitamin C (Vit C) levels on the growth and immunity of fry (1.

Genomic epidemiology of early SARS-CoV-2 transmission dynamics in Bangladesh.

Background: Genomic epidemiology has helped reconstruct the global and regional movement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there is still a lack of understanding of SARS-CoV-2 spread in some of the world's least developed countries (LDCs).

Methods: To begin to address this disparity, we studied the transmission dynamics of the virus in Bangladesh during the country's first COVID-19 wave by analysing case reports and whole-genome sequences from all eight divisions of the country.

Nanomaterial-enabled drug transport systems: a comprehensive exploration of current developments and future avenues in therapeutic delivery.

Over the years, nanotechnology has gained popularity as a viable solution to address gene and drug delivery challenges over conventional methods. Extensive research has been conducted on nanosystems that consist of organic/inorganic materials, drugs, and its biocompatibility become the primary goal of improving drug delivery. Various surface modification methods help focus targeted and controlled drug release, further enabling multidrug delivery also.

Aziridine Group Transfer via Transient -Aziridinyl Radicals.

Aziridines are the smallest nitrogen-containing heterocycles. Strain-enhanced electrophilicity renders aziridines useful synthetic intermediates and gives rise to biological activity. Classical aziridine syntheses─based on either [2 + 1] cycloadditions or intramolecular substitution chemistry─assemble aziridines from acyclic precursors.