Leadless Pacemaker vs. Transvenous Pacemaker in End Stage Kidney Disease: Insights from the Nationwide Readmission Database.

: Leadless pacemakers offer a safe and effective alternative pacing strategy. However, limited data are available for patients with end stage renal disease (ESRD), a population of significant relevance. Using the Nationwide Readmission Database, we extracted data from all adult patients with ESRD who underwent traditional transvenous or leadless pacemaker implantation between 2016 and 2021.

Fenofibrate ameliorated atorvastatin and piperine-induced ROS mediated reproductive toxicity in male Wistar rats.

Atorvastatin and fenofibrate are well-known lipid-lowering drugs. Atorvastatin acts by reducing the production of cholesterol through the inhibition of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG Co-A reductase) enzyme, whereas fenofibrate is a PPAR-α agonist. Piperine is an alkaloid mostly found in black pepper fruits.

Deep Fungal Infections of Skin and Role of Histopathology in Diagnosis.

Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.

Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.

TTFA-Platin Conjugate: Deciphering the Therapeutic Roles of Combo-Prodrug through Evaluating Stability-Activity Relationship.

This work introduces a novel Pt(II) based prodrug TTFA-Platin that integrates a β-diketonate ligand TTFA with a platinum scaffold to structurally resemble carboplatin and offers intermediate kinetic lability between cisplatin and carboplatin, striking a balance between therapeutic efficacy and safety. A comprehensive stability and speciation study was conducted in various biological media, mapping the therapeutic effects of TTFA-Platin. A control molecule, TMK-Platin, was synthesized to further validate the structural-stability relationship, which displayed poor activatable features in biological systems.

Understanding Defect-Mediated Ion Migration in Semiconductors using Atomistic Simulations and Machine Learning.

Ion migration in semiconductor devices is facilitated by the presence of point defects and has a major influence on electronic and optical properties. It is important to understand and identify ways to mitigate photoinduced and electrically induced defect-mediated ion migration in semiconductors. In this Perspective, we discuss the fundamental mechanisms of defect-mediated ion migration and diffusion as understood through atomistic simulations.

Prevalence and Predictors of Anxiety and Depression in Indian Patients with Type 2 Diabetes.

Background: Numerous investigations indicate the presence of a reciprocal association between type 2 diabetes (T2D) and a range of mental health conditions. However, research on the factors that contribute to depression and anxiety in T2D patients in India is scarce.

Purpose: The present study aims to identify the prevalence and predictors of depression and anxiety in patients with T2D in India.

Unusual Sites of Brodie's Abscess and the use of Calcium Sulfate Beads: A Case Series.

Introduction: Brodie's abscess is one type of subacute osteomyelitis without any sequestrum or any systemic illness. Thorough debridement and removal of sclerotic rim are the mainstay of the treatment. Antibiotic-impregnated calcium sulfate (AICS) beads act as osteoconductive and at the same time, it maintains high antibiotic concentration locally.

Syncing online: A methodological investigation into movement synchrony, proxemics, and self-other blurring in virtual spaces.

A growing body of literature has found that synchronising movements with a group subsequently increases self-other blurring and social closeness with synchronised partners. However, movement synchrony has not been studied in online settings. Our study has a primarily methodological focus to investigate whether synchronous movement leads to changes in self-other blurring and proxemics in an online, desktop-mediated environment.

MultiNet 2.0: A lightweight attention-based deep learning network for stenosis measurement in carotid ultrasound scans and cardiovascular risk assessment.

Background: Cardiovascular diseases (CVD) cause 19 million fatalities each year and cost nations billions of dollars. Surrogate biomarkers are established methods for CVD risk stratification; however, manual inspection is costly, cumbersome, and error-prone. The contemporary artificial intelligence (AI) tools for segmentation and risk prediction, including older deep learning (DL) networks employ simple merge connections which may result in semantic loss of information and hence low in accuracy.

Comparative evaluation of efficacy in working length determination: Radiography versus Electronic apex locators using and methods with stereomicroscope validation.

Background: Accurate determination of the working length (WL) is crucial for successful endodontic treatment. Various methods, including radiography and electronic apex locators (EALs), are employed for WL measurement, each with its advantages and limitations.

Aim: This study aimed to compare the accuracy of WL determination using conventional radiography and the Root ZX Mini EAL against an gold standard method.

Health State Utility is Substantially Reduced With an Increasing Burden of Patient-Reported Symptoms in Eosinophilic Esophagitis.

Introduction: We aimed to estimate health state utility in eosinophilic esophagitis (EoE) by histologic activity and assess association with disease parameters.

Methods: In this cross-sectional study, we measured health state utility by time trade-off and assessed symptoms with the EoE Symptom Activity Index.

Results: In 51 adults with EoE, the mean utility was 0.

Thiamine: An indispensable regulator of paediatric neuro-cardiovascular health and diseases.

Unlabelled: The sustainable developmental goals emphasize good health, reduction in preventable neonatal and under-five mortalities, and attaining zero hunger. However, South Asian countries report a higher incidence of neonatal and under-five mortalities when compared to the Western world, many of which are attributed to maternal and perinatal micronutrient deficiencies. Isolated nutrient deficiency in the absence of calorie deficit poses a diagnostic challenge since such deficiencies present with acute multisystemic and enigmatic manifestations.

Screening of novel halide perovskites for photocatalytic water splitting using multi-fidelity machine learning.

Photocatalytic water splitting is an efficient and sustainable technology to produce high-purity hydrogen gas for clean energy using solar energy. Despite the tremendous success of halide perovskites as absorbers in solar cells, their utility for water splitting applications has not been systematically explored. A band gap greater than 1.

Evaluating the potential of 1-methylcyclopropene treatments on physicochemical properties, bioactive compounds, and shelf life of mango fruits under different storage conditions.

The effect of 1-methylcyclopropene (1-MCP) treatments and storage conditions in the regulation of the physicochemical and bioactive properties of mango fruits ( L. cv. BARI-4) were investigated during storage.

Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers.

Stimuli activatable systems have the potential to deliver drugs to targeted areas by releasing therapeutic agents in response to diseased specific microenvironments such as the acidic environment commonly found in diseased tissues. This review article focuses on gossypol, a bioactive compound with inherent toxicity attributed to various factors, including the presence of its formyl groups. It highlights the potential of imine-linked gossypol-based prodrugs and nanoparticle formulations for targeted delivery and controlled release.

A computational approach to developing a multi-epitope vaccine for combating Pseudomonas aeruginosa-induced pneumonia and sepsis.

Pseudomonas aeruginosa is a complex nosocomial infectious agent responsible for numerous illnesses, with its growing resistance variations complicating treatment development. Studies have emphasized the importance of virulence factors OprE and OprF in pathogenesis, highlighting their potential as vaccine candidates. In this study, B-cell, MHC-I, and MHC-II epitopes were identified, and molecular linkers were active to join these epitopes with an appropriate adjuvant to construct a vaccine.

Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer.

Tissue-resident macrophages (TRMs) are an integral part of the innate immune system, but their biology is not well understood in the context of cancer. Distinctive resident macrophage populations are identified in different organs in mice using fate mapping studies. They develop from the yolk sac and self-maintain themselves lifelong in specific tissular niches.

Microneedles: An Efficient Technique to Increase Transdermal Drug Delivery System.

Transdermal Drug Delivery Systems (TDDS) have gained attention as a viable substitute for traditional drug administration methods because of their controlled release capabilities and non-invasive design. Microneedles are a new and effective technology that has attracted a lot of attention recently to enhance the capabilities of TDDS further. The study on microneedles and their potential to improve transdermal medication delivery is thoroughly reviewed in this review article.