Novel carboranyl-BODIPY conjugates: design, synthesis and anti-cancer activity.

A series of four carboranyl-BODIPY conjugates (-CB-10, -CB-15, Me--CB-28, and Me--CB-35) and one phenylene-BODIPY conjugate (PB-20) were synthesized. The carboranyl-BODIPY conjugates incorporate boron clusters, specifically - and -carboranes, covalently linked to BODIPY fluorophores while the phenylene-BODIPY conjugate features a phenylene ring covalently linked to BODIPY fluorophore. The newly synthesized conjugates were characterized by H NMR, C NMR, B NMR, F NMR, FT-IR, and high-resolution mass spectral analysis.

Wavefront sensing with optical differentiation powered by deep learning.

We report the experimental demonstration of an optical differentiation wavefront sensor (ODWS) based on binary pixelated linear and nonlinear amplitude filtering in the far-field. We trained and tested a convolutional neural network that reconstructs the spatial phase map from nonlinear-filter-based ODWS data for which an analytic reconstruction algorithm is not available. It shows accurate zonal retrieval over different magnitudes of wavefronts and on randomly shaped wavefronts.

Telephoto-lens-based Optical Differentiation Wavefront Sensor for freeform metrology.

We report an Optical Differentiation Wavefront Sensor based on a telephoto lens system and binary pixelated filters. It provides a five-fold reduction in the system length compared to a 4f system with identical effective focal length. Measurements of phase plates with this system are compared to measurements performed with a commercial low-coherence interferometer.

Preparation of dendritic carboranyl glycoconjugates as potential anticancer therapeutics.

A series of carborane-appended glycoconjugates containing three and six glucose and galactose moieties have been synthesized Cu(i)-catalyzed azide-alkyne [3 + 2] click cycloaddition reaction. The carboranyl glycoconjugates containing three glucose and galactose moieties were found to be partially water soluble whereas increasing the number to six made them completely water soluble. The evaluation of cytotoxicities and IC values of newly synthesized carboranyl glycoconjugates was carried out using two cancerous cell lines (MCF-7 breast cancer cells and A431 skin cancer cells) and one normal cell line (HaCaT skin epidermal cell line).

High-performance optical differentiation wavefront sensing towards freeform metrology.

We report the demonstration of freeform optics metrology with an optical differentiation wavefront sensor that relies on spatially dithered distributions of binary pixels to synthesize a far-field amplitude filter. Analysis of experimental results and comparison with a commercial low-coherence-length interferometer shows that freeform phase plates with different magnitude of wavefront slopes can be accurately characterized. RMS accuracy of ∼ λ/10 and precision of ∼ λ/70 at 633 nm were achieved with pixelated filters having 2.