Ectatic vertebral artery associated medullary compression treated with microvascular decompression: a case report and review of literature.

Background: Vertebral artery compression syndrome is a rare condition defined as the clinical presentation of dizziness, vertigo, ataxia, dysarthria, dysphagia, progressive or acute paralysis, hemisensory loss, and cervical myelopathy secondary to compression of the medulla and upper spinal cord by the vertebral artery.

Case Description: Here we describe a 57-year-old Mexican-American male with bulbar symptoms, positional vertigo, and diplopia. The patient's symptoms were managed through microsurgical decompression of the medulla utilizing a far lateral transcondylar approach.

Giant primary intracranial multi-fossa leiomyosarcoma involving the frontal sinus, ethmoid air cells, anterior fossa, middle fossa, and intraventricular space: A case report and literature review.

Background: Leiomyosarcomas (LMSs) is a type of sarcoma that arises from smooth muscle and generally presents in the abdomen. Although intracranial LMS has been identified before, most reported presentations have been in immunocompromised patients. Here, we present an intracranial LMS in an immunocompetent patient.

Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization.

To understand how a bacterium ultimately succeeds or fails in adapting to a new host, it is essential to assess the temporal dynamics of its fitness over the course of colonization. Here, we introduce a human-derived commensal organism, Bacteroides thetaiotaomicron (Bt), into the guts of germ-free mice to determine whether and how the genetic requirements for colonization shift over time. Combining a high-throughput functional genetics assay and transcriptomics, we find that gene usage changes drastically during the first days of colonization, shifting from high expression of amino acid biosynthesis genes to broad upregulation of diverse polysaccharide utilization loci.

Utilizing Filipino key informants to guide community outreach for cancer prevention in Hawai'i.

Objective/design: The University of Hawai'i Cancer Center works with academic and community partners to examine health disparities and inequities that persist among Pacific Island Populations through the Pacific Island Partnership for Cancer Health Equity (PIPCHE). The Partnership's Community Outreach Core (COC) assists and promotes cancer research and helps to ensure the integration of historically excluded community perspectives by utilizing community-engaged and culturally-grounded approaches to reduce cancer burdens. However, cancer health disparities among Filipinos demonstrate a need for cancer-control initiatives within this community.

Structure and functional determinants of Rad6-Bre1 subunits in the histone H2B ubiquitin-conjugating complex.

The conserved complex of the Rad6 E2 ubiquitin-conjugating enzyme and the Bre1 E3 ubiquitin ligase catalyzes histone H2B monoubiquitination (H2Bub1), which regulates chromatin dynamics during transcription and other nuclear processes. Here, we report a crystal structure of Rad6 and the non-RING domain N-terminal region of Bre1, which shows an asymmetric homodimer of Bre1 contacting a conserved loop on the Rad6 'backside'. This contact is distant from the Rad6 catalytic site and is the location of mutations that impair telomeric silencing in yeast.

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability.

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in transcription, genome maintenance, and proteostasis. The contributions of many conserved secondary structures of Rad6 and its human homologs UBE2A and UBE2B to their biological functions are not understood. A mutant RAD6 allele with a missense substitution at alanine-126 (A126) of helix-3 that causes defects in telomeric gene silencing, DNA repair, and protein degradation was reported over 2 decades ago.

Numerical Simulation of a Core-Shell Polymer Strand in Material Extrusion Additive Manufacturing.

Material extrusion additive manufacturing (ME-AM) techniques have been recently introduced for core-shell polymer manufacturing. Using ME-AM for core-shell manufacturing offers improved mechanical properties and dimensional accuracy over conventional 3D-printed polymer. Operating parameters play an important role in forming the overall quality of the 3D-printed manufactured products.

The inadequacy of a magnetohydrodynamic approach to the Biermann battery.

Magnetic fields can be generated in plasmas by the Biermann battery when the electric field produced by the electron pressure gradient has a curl. The commonly employed magnetohydrodynamic (MHD) model of the Biermann battery breaks down when the electron distribution function is distorted away from Maxwellian. Using both MHD and kinetic simulations of a laser-plasma interaction relevant to inertial confinement fusion we have shown that this distortion can reduce the Biermann-producing electric field by around 50%.

Spinal Cord Stimulator Paddle Lead Surgery Complicated by Cerebrospinal Fluid Leak and Fistula Formation.

Spinal cord stimulation (SCS) paddle leads placed via laminectomy procedures have become common as more data accumulates with regards to their clinical efficacy. In this paper, we describe a case of a 72-year-old male patient with failed back surgery syndrome (FBSS) who underwent a thoracic laminectomy for permanent paddle lead placement. He went on to develop a complication that resulted in a large cerebrospinal fluid leak with a cerebrospinal fluid fistula formation.

Suppression of the Biermann Battery and Stabilization of the Thermomagnetic Instability in Laser Fusion Conditions.

Magnetic field generated by the Biermann battery is thought to be one of the principal mechanisms behind the inhibition of heat flow in laser-plasma interactions, and is predicted to grow exponentially in some contexts due to the thermomagnetic instability [Tidman and Shanny, Phys. Fluids 17, 1207 (1974)PFLDAS0031-917110.1063/1.

Thermal convection in a magnetized conducting fluid with the Cattaneo-Christov heat-flow model.

By substituting the Cattaneo-Christov heat-flow model for the more usual parabolic Fourier law, we consider the impact of hyperbolic heat-flow effects on thermal convection in the classic problem of a magnetized conducting fluid layer heated from below. For stationary convection, the system is equivalent to that studied by Chandrasekhar ( 1961), and with free boundary conditions we recover the classical critical Rayleigh number [Formula: see text] which exhibits inhibition of convection by the field according to [Formula: see text] as [Formula: see text], where is the Chandrasekhar number. However, for oscillatory convection we find that the critical Rayleigh number [Formula: see text] is given by a more complicated function of the thermal Prandtl number [Formula: see text], magnetic Prandtl number [Formula: see text] and Cattaneo number .

On oscillatory convection with the Cattaneo-Christov hyperbolic heat-flow model.

Adoption of the hyperbolic Cattaneo-Christov heat-flow model in place of the more usual parabolic Fourier law is shown to raise the possibility of oscillatory convection in the classic Bénard problem of a Boussinesq fluid heated from below. By comparing the critical Rayleigh numbers for stationary and oscillatory convection, and respectively, oscillatory convection is found to represent the preferred form of instability whenever the Cattaneo number exceeds a threshold value ≥8/27≈0.03.

Content and construct validity of Here's How I Write (HHIW): A Child's Self-Assessment and Goal Setting Tool.

Objective: We examined content and construct validity of Here's How I Write: A Child's Self-Assessment and Goal Setting Tool, to assess children's perception of their handwriting and set child-directed goals.

Method: In Study 1, a content validity study, 6 occupational therapists and 2 educators assessed the need for this type of measure and examined the proposed items. Thirty-four occupational therapists and educators then completed an online survey examining the items.

Field compressing magnetothermal instability in laser plasmas.

The mechanism for a new instability in magnetized plasmas is presented and a dispersion relation derived. Unstable behavior is shown to result purely from transport processes-feedback between the Nernst effect and the Righi-Leduc heat-flow phenomena in particular-neither hydrodynamic motion nor density gradients are required. Calculations based on a recent nanosecond laser gas-jet experiment [D.

Providing occupational therapy using sensory integration theory and methods in school-based practice.

AOTA recognizes SI as one of several theories and methods used by occupational therapists and occupational therapy assistants working with children in public and private schools. Regardless of the theories and methods utilized, occupational therapy practitioners work within the framework of occupational therapy toward the desired outcome of health and participation through engagement in occupations that allow participation in a child's daily life (AOTA, 2008). When children demonstrate sensory-related deficits that interfere with their ability to access the general education curriculum, occupational therapy using a sensory integrative approach is appropriate.

Polymeric acrylate-based hybrid films containing lead and iron patterned by UV photo-polymerization.

The development and processing of hybrid inorganic-organic thin film materials plays a critical role in advancing interdisciplinary sciences and device manufacturing. Here we present a novel approach to synthesize and deposit acrylate-containing organic/inorganic hybrid films. The material is based on a chemical solution and includes specifically desired metal dopants that are fully integrated into the backbone of the polymer structure.

Sibling relationship, family, and genetic factors in sibling similarity in sexual risk.

Siblings' risky attitudes toward sex and pregnancy and risky sexual behavior were studied in 1583 dyads from the National Longitudinal Study of Adolescent Health. We tested moderators of the links between 2 siblings' reports of sexual risk as well as mediators of the links between siblings' genetic similarity and similarity in their sexual risk. Siblings' sexual risk reports were correlated, and consistent with social learning predictions, associations were stronger between siblings with close relationships and in same-gender dyads and, to a lesser extent, between more genetically similar siblings and those closer in age.

Expression of beta-defensins in gingival health and in periodontal disease.

Background: Human beta-defensins (HBDs) are epithelial-derived antimicrobial peptides. The expression of three HBDs (HBD-1, HBD-2, and HBD-3) has been reported in oral mucosa, gingiva, and salivary glands. However, their role in protection against oral infections is not well understood.

Applying sensory integration framework in educationally related occupational therapy practice (2003 statement).

Based on the educational team recommendations, occupational therapists and occupational therapy assistants working in educationally related settings provide services to students who are eligible for Section 504 or special education under IDEA and need occupational therapy to benefit from their education program. It is the occupational therapist's responsibility to develop an intervention plan based on the student's needs and the therapist's professional knowledge base. The occupational therapist chooses and applies any frame of reference within the domain and process of occupational therapy.

Therapeutic modalities in hand surgery.

Therapeutic modalities are useful adjuncts in the rehabilitation of many patients commonly seen by hand surgeons. Therapeutic heat, cold, electrical stimulation, and laser and magnetic field treatments are evaluated for their respective mechanisms of action, indications, contraindications, and clinical results. The majority of therapeutic modalities have been extensively investigated and relevant basic science and randomized well-controlled clinical studies addressing the efficacy of therapeutic modalities are emphasized.

Regulation of a human cytomegalovirus immediate-early gene (US3) by a silencer-enhancer combination.

The US3 open reading frame of human cytomegalovirus (HCMV) is transcribed at immediate-early (IE) times after infection. Upstream of the US3 promoter, between -84 and -259 bp relative to the transcription start site, there are five copies of an 18-bp repeat, referred to as 5R2. Between -340 and -560 bp there are seven copies of a 10-bp dyad repeat, referred to as 7R1.

Dichotic listening performance in normal children and adults.

The purpose of this study was to investigate normative expectations on the dichotic listening test in order to determine the influence of sex and development on dichotic listening performance. Thirty 5-to-6 year olds, thirty 11-to-12 year olds, and 30 adults, 15 males and 15 females in each group, were tested by using consonant-vowel dichotic stimuli. There were no significant differences between males and females except for the 11- to 12-year-old females who were significantly more accurate than the males.

The use of crafts in occupational therapy for the physically disabled.

In this article, the historical use of crafts in occupational therapy for the physically disabled patient is reviewed and the results of a survey aimed at describing current craft use is presented. A questionnaire was sent to a random sample of 250 occupational therapists throughout the United States who chose physical disabilities as their specialty section. Results demonstrated that, while most therapists use crafts to some degree in their therapy programs, other treatment modalities such as therapeutic exercise and activities of daily living were used a greater percentage of the time.

Criteria for same and different judgments and visual comparison strategies of four-year-olds.

4-year-olds made same and different judgments about pairs of stimuli requiring detailed comparison in 2 conditions: a judgment-only condition and a justification condition in which children explained the reasons for their judgments. The systematic comparison strategies revealed in the justifications indicated that all children had definite criteria for "same" and "different" although about two-thirds of the children used a criterion that differed from the adult criterion. Judgments were more accurate in the justification than in the judgment-only condition, suggesting that overt verbalizations and gestures may provide a beneficial external support for completion of a child's own visual comparison strategy.