Publications by authors named "Bisola Laguda"
Objectives: To characterize the clinical presentation, possible trigger factors and seasonality of acute urticaria (AU) in children referred to the emergency department in a teaching hospital in London, United Kingdom.
Methods: This was a retrospective descriptive study. One hundred and sixty-three consecutive patients younger than 18 years with the diagnosis of AU who attended accident and emergency department from January 2018 until January 2020 at Chelsea and Westminster Hospital in London, United Kingdom, were included in the study.
Article Synopsis
- There is a lack of strong evidence for effective treatments for juvenile localized scleroderma (JLS), with methotrexate (MTX) as the first-line choice and mycophenolate mofetil (MMF) as a second option, prompting the need for head-to-head trials to assess their relative benefits.
- An international expert meeting aimed to gather opinions on the efficacy and tolerability of MTX and MMF, which revealed that experts believe MMF may be superior in both areas, although there is still uncertainty among them.
- The study emphasizes the importance of utilizing a Bayesian approach for designing future clinical trials to integrate expert opinions and reduce pre-trial uncertainty, despite requiring a large sample size of 240
Background: Systematic reviews suggest that narrowband ultraviolet B light combined with treatments such as topical corticosteroids may be more effective than monotherapy for vitiligo.
Objective: To explore the clinical effectiveness and cost-effectiveness of topical corticosteroid monotherapy compared with (1) hand-held narrowband ultraviolet B light monotherapy and (2) hand-held narrowband ultraviolet B light/topical corticosteroid combination treatment for localised vitiligo.
Design: Pragmatic, three-arm, randomised controlled trial with 9 months of treatment and a 12-month follow-up.
We identified and clinically investigated two patients with primary erythromelalgia mutations (PEM), which are the first reported to map to the fourth domain of Nav1.7 (DIV). The identified mutations (A1746G and W1538R) were cloned and transfected to cell cultures followed by electrophysiological analysis in whole-cell configuration.
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