Isatuximab for Stem Cell Transplant-Ineligible Multiple Myeloma: An Editorial.

The recent approval of isatuximab in combination with bortezomib, lenalidomide, and dexamethasone (Isa-VRd) marks a significant advancement in the treatment of stem cell transplant-ineligible multiple myeloma (MM) patients. MM, the second most common hematological malignancy globally, poses substantial challenges, especially for patients who are unable to undergo autologous stem cell transplantation due to advanced age or comorbidities. Isatuximab, a CD38-targeting monoclonal antibody, has demonstrated promising efficacy in the pivotal trial, which reported a 40% reduction in disease progression or death for patients treated with Isa-VRd compared to bortezomib-lenalidomide-dexamethasone alone.

Women's knowledge and attitudes to the menopause: a comparison of women over 40 who were in the perimenopause, post menopause and those not in the peri or post menopause.

Objectives: To evaluate women's knowledge and attitudes towards the menopause by comparing three groups of women: perimenopause, post menopause and those women not in either the peri or post menopause (other).

Methods: A 35 question online survey was advertised on social media to evaluate women's attitudes and knowledge of the menopause. Three groups of women were compared: perimenopause, post menopause and those women not in either the peri or post menopause (other).

Development of One Pot Strategy for Hyper Production and In Vivo Evaluation of Lovastatin.

The aim of this project was to improve the strain and pretreatment of sugarcane bagasse as carrier substrate for bulk production of lovastatin, a cholesterol-lowering drug, in solid state fermentation. Sugarcane bagasse was treated with alkali (1-3% NaOH) for the conversion of complex polysaccharides into simple sugars for better utilization of carrier substrate by microorganism for maximum lovastatin production. Ethidium bromide (time of exposure 30-180 min) was used to induce mutation in and the best mutant was selected on the basis of inhibition zone appeared on petri plates.