Publications by authors named "Bishoy F Hanna"
Spinal cord injury (SCI) is a devastating condition affecting 270,000 people in the United States. The use of growth factors is a potential treatment for reducing secondary damage, promoting axon growth, and restoring some of the lost function post-SCI. Glial cell line-derived neurotrophic factor (GDNF) is an important growth factor, because it can affect both neurons and support cells.
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- Spinal cord injury (SCI) affects around 270,000 individuals in the U.S., and interleukin-10 (IL-10) could serve as a potential treatment by reducing inflammation and neuronal damage associated with the condition.
- IL-10 works by decreasing harmful pro-inflammatory substances and promoting anti-apoptotic factors, while also providing support to neurons, leading to better tissue preservation and recovery when administered right after an SCI.
- However, while localized IL-10 delivery methods show promise, chronic systemic administration may have negative effects, indicating that more research is necessary for optimal delivery and dosage strategies.