Gut Microbiota and Metabolites Mediate Health Benefits of Oat and Oat Bran Consumption in IBD Mice.

Background/objectives: Inflammatory bowel disease (IBD) is a chronic condition influenced by a variety of factors, including genetics, the environment, and gut microbiota. The incidence of IBD is increasing globally. Previous studies have shown that interactions between diet and gut microbiota influence the pathogenesis and treatment of IBD.

Black goji berry anthocyanins extend lifespan and enhance the antioxidant defenses in Caenorhabditis elegans via the JNK-1 and DAF-16/FOXO pathways.

Background: The black goji berry (Lycium ruthenicum Murr.) is known for its abundance of high-quality natural antioxidants, particularly anthocyanins. Black goji berry anthocyanins (BGA) are receiving increasing attention because of their high safety and beneficial biological activities.

Extract Enriched with Ursolic Acid Ameliorates UVB-Induced Photoaging in .

Ultraviolet B (UVB) exposure can contribute to photoaging of skin. is rich in ursolic acid (UA), which is beneficial to the prevention of photoaging. Because UA is hardly soluble in water, the extract (COE) was obtained using water as the antisolvent to separate the components containing UA from the crude extract of .

extract exhibited antioxidant effects to promote longevity and stress resistance in .

In this study, we explored the lifespan extension effect of a popular edible mushroom, , using the model organism (). The results showed that extract (HME) could increase the lifespan of and ameliorate the healthspan by improving motility, attenuating lipofuscin accumulation, and enhancing the ability to withstand oxidative and heat stress. Then, we found noteworthy enhancements in SOD and CAT activities and reactive oxygen species (ROS) scavenging activity .

Apple peel polyphenol alleviates antibiotic-induced intestinal dysbiosis by modulating tight junction proteins, the TLR4/NF-κB pathway and intestinal flora.

The intestine and its flora have established a strong link with each other and co-evolved to become a micro-ecological system that plays an important role in human health. Plant polyphenols have attracted a great deal of attention as potential interventions to regulate the intestinal microecology. In this study, we investigated the effects of apple peel polyphenol (APP) on the intestinal ecology by establishing an intestinal ecological dysregulation model using lincomycin hydrochloride-induced Balb/c mice.

Production and Anti-Inflammatory Performance of PVA Hydrogels Loaded with Curcumin Encapsulated in Octenyl Succinic Anhydride Modified Schizophyllan as Wound Dressings.

Amphiphilic polysaccharides can be used as wall materials and applied to encapsulate hydrophobic active chemicals; moreover, there is significant demand for novel medical high-molecular-weight materials with various functions. In order to prepare amphiphilic schizophyllan (SPG), octenyl succinic anhydride (OSA) was chosen to synthesize OSA-modified schizophyllan (OSSPG) using an esterified reaction. The modification of OSSPG was demonstrated through FT-IR and thermal analysis.

High-voltage pulse-assisted extraction of flavonoids from kapok using deep eutectic solvent aqueous solutions.

In this study, deep eutectic solvents coupled with a pulsed electric field (PEF-DES) were first applied to the extraction of traditional Chinese medicine plants. This study uses the PEF-DES extraction technique to extract TG-KF (Kapok flavonoid solution extracted with DES-TG). PEF-DES is a simple, effective and environmentally-friendly technology and can be used in industrial-scale production.

Phytochemical Profiles, Antioxidant Activity and Antiproliferative Mechanism of L. Phenolic Extract.

The phenolic profiles, antioxidant activity, antiproliferative property and the underlying molecular mechanisms of cell apoptosis of free phenolic (RFE) were analyzed in this work. Overall, rhizome phenolic extract (RE) contained rhizome free phenolic extract (RFE) and rhizome bound phenolic extract (RBE). Compared with RBE, RFE contained higher phenolic contents and possessed stronger antioxidant activity.

Quantification of Phytochemicals, Cellular Antioxidant Activities and Antiproliferative Activities of Raw and Roasted American Pistachios ( L.).

The consumption of pistachios has been linked to many potential health benefits. Phytochemicals in pistachios, including phenolics, vitamin E and carotenoids, have been considered to make contributions to the health benefits. The objectives of this study were (1) to explore the phytochemical profiles (total phenolics and total flavonoids, including both free and bound forms), selected phytochemicals, vitamin E and carotenoids of raw and roasted pistachios; (2) to determine total antioxidant activity and cellular antioxidant activity (CAA); and (3) to explore antiproliferative activities of pistachio extracts against human breast, liver and colon cancer cells in vitro.

DAF-16 is involved in colonic metabolites of ferulic acid-promoted longevity and stress resistance of Caenorhabditis elegans.

Background: Ferulic acid (FA) is a dietary polyphenol widely found in plant tissues. It has long been considered to have health-promoting qualities. However, the biological properties of dietary polyphenols depend largely on their absorption during digestion, and the effects of their intestinal metabolites on human health have attracted the interest of researchers.

The effect of gastrointestinal digestion on the phenolic profiles, bioactivities and bioaccessibility of .

Changes in the phenolic profiles and antioxidant and antiproliferative activities of after simulated digestion were first assessed in this study. Furthermore, permeability and uptake assays as well as RT-qPCR and western blot analyses were performed in order to explore the bioaccessibility of the digesta and its underlying mechanism. The results reveal that gastrointestinal digestion significantly reduced the total phenolics and total flavonoids as well as the extracellular, cellular antioxidant and antiproliferative activities of , in which the colon digesta had the largest reduction.

Enhanced exopolysaccharide yield and antioxidant activities of fermented products by the addition of Radix Puerariae.

To increase the production of exopolysaccharides (EPS) and expand the application of () fermentation liquid, the traditional Chinese medicine Radix Puerariae (RP) with outstanding biological activity was selected as a culture additive to improve the EPS yield and enhance the antioxidant activity of fermented products from . The effects of three independent factors: A: initial pH (5.0-6.

Mechanism of Longevity Extension of Induced by Fermented Supernatant With Added Radix Puerariae.

() fermented supernatant with added Radix Puerariae (SC-RP) showed significant antioxidant activity in our previous work. However, the possible lifespan and healthspan extending the capacity of () and the underlying mechanism were not illuminated. In this study, the effect of SC-RP on extending the lifespan and improving stress resistance of were examined.

Comparison of phytochemical profiles, antioxidant and antiproliferative activities in Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruits.

Here, we examined the phytochemical profiles, antioxidant activity (AA), and antiproliferative activity (APA) of four Chinese bayberry (Myrica rubra Sieb. et Zucc.) pulp extracts.

HSF-1 and SIR-2.1 linked insulin-like signaling is involved in goji berry (Lycium spp.) extracts promoting lifespan extension of Caenorhabditis elegans.

The anti-cancer, vision-improving, and reproduction-enhancing effects of goji berry have been generally recognized, but its role in anti-aging is rarely studied in depth. Therefore, two widely-circulated goji berries, Lycium ruthenicum Murr. (LRM) and Lycium Barbarum.

Goji berry ( spp.) extracts exhibit antiproliferative activity modulating cell cycle arrest, cell apoptosis, and the p53 signaling pathway.

The phytochemical profiles, antioxidant activity and antiproliferative mechanism of two goji berry varieties were investigated in the present study. In contrast to Lycium barbarum L. (LB), Lycium ruthenicum Murr.

Rhodiola extract promotes longevity and stress resistance of Caenorhabditis elegans via DAF-16 and SKN-1.

The effects of Rhodiola extract (RE) on longevity and stress resistance in Caenorhabditis elegans (C. elegans), and the underlying molecular mechanisms were explored in the present study. Results showed that the lifespan of C.

Wild pink bayberry fruit: the effect of gastrointestinal digestion on phytochemical profiles, and antioxidant and antiproliferative activities.

The regular consumption of polyphenol-rich foods is essential to prevent the onset of diseases. Wild fruits are known to possess higher levels of bioactive components than the domesticated fruits because of the severe environmental conditions they are grown in. The aim of this study was to evaluate the phytochemical profiles, and antioxidant and antiproliferative activities of a wild pink bayberry fruit after in vitro digestion and to compare them with results obtained with a chemical extraction method.

Effects of ethyl acetate fractional extract from Portulaca oleracea L. (PO-EA) on lifespan and healthspan in Caenorhabditis elegans.

Portulaca oleracea L. (PO), with abundant natural bioactive phytochemicals, exhibits potential bioactivities and pharmacological activities. However, the mechanisms of action of PO on anti-aging effect remain unclear.

IRS-1/PI3K/Akt pathway and miRNAs are involved in whole grain highland barley ( L.) ameliorating hyperglycemia of db/db mice.

The effects of whole grain highland barley (WGH) with rich phenolics on glucose metabolism, the insulin pathway, and microRNA (miRNA) expression in db/db mice were explored in the present study. Supplementation with WGH decreased the levels of blood glucose, glycosylated serum protein (GSP), insulin, and inflammatory cytokines in db/db mice. Furthermore, WGH administration triggered a remarkable amelioration of glucose intolerance and insulin resistance.

Fabrication, characterization and evaluation of myricetin adsorption onto starch nanoparticles.

Myricetin (MY) is a natural antioxidant flavonoid with a variety of biological activities. However, extremely low water solubility, bioavailability, and easy degradation, restrict their application. Recently, increasing interest in starch nanoparticles as a new kind of biocompatible renewable polymer in applications like nanocarriers.

Highland Barley Whole Grain () Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice.

The mechanisms of highland barley whole grain (BWG) with rich phenolics on obese db/db mice were investigated in this study. Oral consumption of BWG reduced food intake, body weight, organ/body weight indexes of liver and fat, levels of serum and hepatic lipids, liver injury, and oxidative stress. Furthermore, BWG recovered the disorder of cecal microbiota by augmenting the / ratio and abundance and decreasing the abundances of and to modulate lipid metabolism-related genes.

Phenolic profiles, antioxidant, antiproliferative, and hypoglycemic activities of Ehretia macrophyla Wall. (EMW) fruit.

Phenolic profiles, antioxidant, antiproliferative, and hypoglycemic activities of the whole Ehretia macrophylla Wall. (EMW) fruit were investigated in the present study. Catechin (CE), o-methoxy benzoic acid (o-MBA), and rosmarinic acid (RA) were the predominant phenolics in free extract, while CE, vanillic acid (VA), and o-MBA were for bound extract.

Combination of apple peel and blueberry extracts synergistically induced lifespan extension via DAF-16 in Caenorhabditis elegans.

Increased consumption of fruit and vegetables is associated with a reduced risk of age-related functional decline and chronic diseases, which is primarily attributed to their phytochemicals. Apples and blueberries are rich in phytochemicals with a wide range of biological activities and health benefits. The objective of this study was to determine whether the combination of apple peel extracts (APE) and blueberry extracts (BE) had synergistic effects in promoting lifespan in Caenorhabditis elegans (C.

Comparison of phenolics, antioxidant, and antiproliferative activities of two Hypsizygus marmoreus varieties.

Phenolics, antioxidant activities, and antiproliferative properties of brown Hypsizygus marmoreus (brown HM) and white Hypsizygus marmoreus (white HM) were compared. The results showed that the contents of (+)-catechin, gallic acid, and protocatechuic acid of brown HM were higher than those of white HM. Moreover, brown HM had greater cellular antioxidant activity (CAA), peroxyl radical scavenging capacity (PSC), and oxygen radical absorbance capacity (ORAC) values than white HM, which demonstrated that brown HM presented a stronger antioxidant capacity.