Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines.

Objective And Design: The purpose of this study was to elucidate the probable mechanism for the anti-arthritic activity of agnuside (AGN), a compound isolated from the leaf extract of Vitex negundo.

Methodology: The anti-inflammatory activity of AGN within a dose range of 1.56-12.

Cytotoxic evaluation and induction of mitochondria-mediated apoptosis in human leukaemia HL-60 cells by Carissa spinarum stem isolate.

Objective: To evaluate Carissa spinarum stem isolate for its anti-cancer therapeutic potential.

Methods: The n-butanol fraction of aqueous extract from Carissa spinarum stem was assessed for its cytotoxic and pro-apoptotic activity.

Key Findings: We report for the first time the anti-cancer potential of C.

Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa.

Inula racemosa Hook.f. commonly known as Pushkarmula (Compositae) has been used as a traditional drug in India, China and Europe.