Publications by authors named "Bisalla Mohammed"
Background: Due to its affordability in disease-affected communities and suitability for field application, microscopy has historically been considered the gold standard for field diagnosis of trypanosomosis in rural settings.
Aim: This works aims to compare the performance of microscopists on bovine trypanosome microscopy by organizing the first comparative assessment on a correct reading of slides by laboratory professionals using the read slide results and a structured interviewer-administered questionnaire in North-central Nigeria.
Methods: Ten participants were addressed, as they were sent a panel of two slides (Slide 1: No Trypanosome present; Slide 2: Trypanosome present) and a questionnaire.
Time of drug administration affects both the kinetics and dynamics of medications. This study investigated diurnal efficacy of alpha-lipoic acid (ALA), nifedipine, and glimepiride combination in the treatment of diabetic retinopathy. The study design comprised seven groups of rats, with groups 1 and 2 serving as non-diabetic and diabetic controls, respectively, receiving 1 ml/kg distilled water.
View Article and Find Full Text PDFSitagliptin- oleifera coadministration did not delay the progression nor ameliorated functional and morphological anomalies in alloxan-induced diabetic nephropathy.
Indian J Pharmacol
September 2018
Objective: Sitagliptin (ST) and (MO) Lam (Moringaceae) are used concomitantly by diabetic patients, with no study ascertaining for potential favorable or otherwise renal implications. We investigated the effect of coadministration of ST and MO leaf extract on functional and morphological biomarkers of alloxan-induced diabetic nephropathy (DN).
Materials And Methods: Diabetes was induced with a single dose of 150 mg/kg of alloxan intraperitoneally.
Article Synopsis
- The study examined the health effects of chronic low-dose exposure to lead (Pb), cadmium (Cd), and manganese (Mn) in rats over 15 weeks, focusing on dyslipidaemia and oxidative stress.
- Results showed that while serum lipid profiles weren't significantly altered, there was a notable decrease in the atherogenic index and triglyceride/HDL cholesterol ratio in the group exposed to all three metals combined (Pb+Cd+Mn).
- Increased levels of malondialdehyde (an oxidative stress marker) were observed along with a decrease in protective proteins like glutathione peroxidase-1, indicating prolonged exposure may lead to hypolipidaemia and associated health risks for those exposed to environmental levels of
Ethnopharmacological Relevance: Moringa oleifera Lam. (Moringaceae) has gained awareness for its antidiabetic effect, and is used as alternative therapy or concurrently with orthodox medicines such as sitagliptin in diabetes mellitus. This is without ascertaining the possibility of drug-herb interactions, which could either lead to enhanced antidiabetic efficacy, increased toxicity, or compromised glycaemic control with negative consequence in diabetic retinopathy.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the harmful effects of long-term exposure to low doses of lead, cadmium, and manganese on liver and kidney toxicity in young male rats, highlighting significant changes in serum protein levels and enzyme activity.
- - Young Wistar rats were given various combinations of these heavy metals over 15 weeks, leading to increased globulin levels and altered creatinine levels, indicating kidney stress, especially in the manganese group.
- - Findings showed that both hepatic and renal tissue experienced oxidative stress and degenerative changes, emphasizing the need to study these metals' effects together to understand their combined impact on health.
Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub-chronic co-administration of chlorpyrifos and cypermethrin in male Wister rats.
Asian Pac J Trop Biomed
April 2014
Objective: To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats.
Methods: Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given distilled water and soya oil (2 mL/kg) respectively.
Background: Lamivudine and artesunate are sometimes co administered in HIV-malaria co morbidity. Both drugs are used concurrently in presumptive malaria treatment and simultaneous HIV post exposure prophylaxis.
Aim: The aim of this study was to investigate the effect of lamivudine-artesunate co administration on the histology of the liver of diseased adult Wistar rats.