rs1840680 single nucleotide polymorphism in Pentraxin 3: a potential protective biomarker of severe community-acquired pneumonia.

Objective: Single nucleotide polymorphisms (SNPs) of () are associated with various outcomes of lung infections. This study aimed to analyze the relationship between polymorphisms and the severity of community-acquired pneumonia (CAP).

Methods: This is a retrospective case-control study comprising 43 patients with severe CAP (SCAP) and 97 patients with non-severe CAP.

Pentraxin-3 polymorphisms and pulmonary fungal disease in non-neutropenic patients.

Background: Pentraxin 3 (PTX3) plays a non-redundant role in innate immunity against fungal diseases. Although single nucleotide polymorphisms (SNPs) of PTX3 are associated with a higher risk of invasive aspergillosis among the immunosuppressed population and chronic obstructive pulmonary disease patients, it is unknown whether PTX3 genetic variants influence the risk of pulmonary fungal disease in immunocompetent patients.

Methods: To investigate the association between gene polymorphisms and pulmonary mycosis in non-neutropenic patients, we conducted a case-control study in a tertiary hospital department.