Is Willebrand Factor Indicative of Chronic Inflammation in Children with Asthma?

Objective: To improve our knowledge and to understand how the level of von Willebrand factor indicates the development of chronic inflammation in children with recurrent wheezing and asthma.

Material And Methods: It was a prospective cohort study. This study was conducted in children with recurrent wheezing and asthma who were referred to a children's hospital during 2017-2018.

Binding of Coagulation Factor XIII Zymogen to Activated Platelet Subpopulations: Roles of Integrin αIIbβ3 and Fibrinogen.

Factor XIIIa (fXIIIa) is a transglutaminase that plays a crucial role in fibrin clot stabilization and regulation of fibrinolysis. It is known to bind to procoagulant platelets. In contrast, the zymogen fXIII interaction with platelets is not well characterized.

Interrelationship of endothelial function parameters in children with bronchial asthma in exacerbation and remission.

Introduction: In children with asthma, endothelial dysfunction signs are observed, and their extent depends on the severity of the disease. These changes are also present in remission. High level of soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) expression causes active adhesion of inflammatory cells and can indicate direct endothelium participation in development and supporting of chronic inflammation.

[The effect of "aging" of fibrinogen molecule on the structure and properties of fibrin gel].

The effect of molecular "aging" of fibrinogen stimulated by preincubation in solution on the fibrin three-dimensional architecture, its ability to crosslink fibrin-stabilizing factor, and the sensitivity of fibrin gel to plasmin hydrolysis have been studied. The method of elastic light scattering was used to demonstrate that fibrin generated from "defective" fibrinogen had a coarser structure with a higher mean mass-length ratio of polymeric fibers compared to native fibrinogen (2.24 x 10(9) and 1.

[Influence of end products of plasmin-mediated hydrolysis of fibrinogen and fibrin (EF and Ef fragments) on fibrinogen cross-linking].

We studied the influence of the end products of plasmin-mediated hydrolysis of fibrinogen and nonstabilized fibrin (EF and Ef fragments) on covalent cross-linking of fibrinogen molecules catalyzed by a fibrin-stabilizing factor (factor XIIIa). The data on elastic and dynamic light scattering reveal no difference in the spatial structure of covalently linked fibrinogen molecules in the presence of the hydrolysis end products EF and Ef. In contrast to the inactive fragment EF, fragment Ef significantly accelerates the enzymatic reaction.

[The relationship of endocrine ophthalmopathy to the thyroid status and to the indices of an autoimmune lesion of the thyroid].

The paper is devoted to a study of the pathogenetic relationship of endocrine ophthalmopathy with thyroid diseases. Altogether 76 patients with endocrine ophthalmopathy combined with various thyroid lesions (diffuse toxic goiter, Hashimoto's disease, primary hypothyrosis) and without thyroid diseases were investigated. The serum level of thyroid hormones, the content of Ig A, M, G, thyroglobulin and the presence of antithyroid antibodies were analyzed.

[Thyroid antibodies in autoimmune diseases of the thyroid and their dependence on the presence of autoantigens].

Autoimmune thyroid diseases (especially diffuse toxic goiter) are characterized by a higher frequency of the detection and concentration of serum thyroglobulin. The frequency of the detection of antibodies to thyroglobulin in Hashimoto's thyroiditis was higher and their concentration lower than in diffuse toxic goiter. The frequency of the detection of antibodies to microsomal thyroid antigen in autoimmune thyroid diseases was lower than that of antibodies to thyroglobulin and did not depend on a type of disease.

[Structure of the mammillary bodies of the hypothalamus of the bottlenosed dolphin].

In the bottlenosed dolphin (Tursiops truncatus) the hypothalamic corpus mammillaris has been studied using interperpendicular, sagittal, frontal and horizontal serial sections, impregnated in silver and stained with cresil-violet. Comparatively small dimentions of the corpora mammillaria in the bottlenosed dolphin are explained by presence of only two nuclei, medial and lateral. The lateral nucleus is nearly three times as large as the medial one.

[Myeloarchitectonics of the hypothalamic mammillary bodies in the bottle-nosed dolphin].

The topography of the main fibrillar bundles realizing the neural connections of the corpora mamillare of the dolphin (Tursiops truncatus) hypothalamus has been studied using sagittal, frontal and horizontal serial sections impregnated with silver nitrate and stained with cresil violet. The dolphin main afferent (fornix, mamillary peduncles) and efferent--mamillary-thalamic, mamillary-tegmental tracts--of the corpora mamillare--have an original topography and dimensions distinctive from those of terrestrial mammals, the human being including.

[Treatment of congestive heart failure with beta-methyldigoxin (lanitop)].

Methylated Digoxin preparation--beta-Methyldigoxin (Lanitop) was used in 50 patients with congestive heart failure of different etiology (tablets of 0.3--0.6 mG per day).

[Morphology of the synaptic apparatus of the motor neurons of the frog's spinal cord].

The method of light microscopy was used in order to study the synapses of motor neurons of the thoracic and lumbar parts of the spinal cord of intact frogs. Under study were the shape of the synapses, their size, as well as the quantitative distribution on the bodies and dendrites of neurons. It was established that the distribution density of active synaptic terminations on the motor neurons of the lumbar part was higher than the density of active synapses in the thoracic part, and the amount of synaptic terminations on dendrites was greater than on the neuron bodies; the snyaptic terminations of different shape were different in size; the occurrence of certain shapes of synaptic terminations in the thoracic and lumbar parts was almost the same.