Publications by authors named "Birgit Sauter"
Article Synopsis
- - Warthin tumors are common benign salivary gland tumors, but there is limited understanding of their genetic changes and tumor development.
- - The study analyzed 30 tumors using comparative genomic hybridization (CGH) and confirmed previous findings, identifying key genetic alterations including deletions on chromosomes 8, 9, 16, and 22.
- - Two distinct patterns of chromosomal changes emerged, suggesting that Warthin tumors could be categorized into two genetic groups, which may relate to differences in their clinical presentation.
Background: Despite numerous studies, the tumor biology of pleomorphic adenomas, the most common salivary gland tumors, is still not completely defined. In order to identify further candidate genes important for tumor biology of pleomorphic adenomas, extended cytogenetic and molecular analysis are mandatory.
Methods: We performed a detailed molecular cytogenetic analysis using comparative genomic hybridization (CGH) followed by fluorescence in situ hybridization (FISH) with probes for chromosome X, 16p, 17, and 20 on a large cohort of pleomorphic adenomas (n = 29).