Publications by authors named "Birgit Rinn"
Article Synopsis
- The cytokine MIF promotes tumor cell growth and prevents apoptosis in malignant glioblastoma by influencing cell-cycle progression and angiogenesis.
- In vitro experiments demonstrated that reducing MIF levels in glioblastoma cells led to decreased growth rates, especially under conditions that typically prevent cell proliferation (contact inhibition).
- Findings also revealed that MIF plays a crucial role in maintaining uncontrolled cell growth by modulating proteins associated with contact inhibition, suggesting that targeting MIF could be a potential therapeutic strategy for treating glioblastomas.
MIF has been described as a protein that plays an essential role in both innate and acquired immunity. Previous studies have demonstrated that MIF activates lymphocytes, granulocytes and monocytes/macrophages. Furthermore, MIF can counteract the physiological function of steroids, thus playing a role in immune system regulation.
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