Publications by authors named "Birgit Pateter"
Knowledge about the impact of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the elderly on mRNA vaccination response is needed to appropriately address the demand for additional vaccinations in this vulnerable population. Here, we show that octogenarians, a high-risk population, mount a sustained SARS-CoV-2 spike-specific immunoglobulin G (IgG) antibody response for 15 months following infection. This response boosts antibody levels 35-fold upon receiving a single dose of BNT162b2 mRNA vaccine 15 months after recovery from coronavirus disease 2019 (COVID-19).
View Article and Find Full Text PDFArticle Synopsis
- Research indicates that understanding how prior SARS-CoV-2 infection affects mRNA vaccination responses in the elderly is crucial for determining the need for booster shots.
- In a study involving 16 elderly participants who received a single booster dose of the BNT162b vaccine, antibody levels rose dramatically from an average of 710 U/ml to over 40,000 U/ml within ten weeks post-vaccination.
- In contrast, a comparison group of younger, uninfected individuals exhibited lower antibody levels, and their immune response was transient, while the elderly group displayed a more robust and lasting immune response.