Cardiomyocyte survivin protein expression is associated with cell size and DNA content in the failing human heart and is reversibly regulated after ventricular unloading.

Background: Mechanical support in congestive heart failure (CHF) by a left ventricular assist device (LVAD) is associated with decreased cardiac hypertrophy and altered cardiomyocyte molecular pathways. Survivin initiates cell cycle progression by increased cyclinD1/cdk4 complexes by abrogation of the inhibitory effect of p16(INK4a) on cdk4. Accordingly, the role of survivin in CHF and after unloading was explored.

Interocclusal clearance during speech and in mandibular rest position. A comparison between different measuring methods.

Background And Aim: The interocclusal clearance during speech and in mandibular rest position shows an interindividual variation and influences the stability of prosthodontic reconstruction or orthodontic therapy, especially in patients with deep bite or cover-bite. Exact determination of the vertical dimension, not always a simple matter in practice, is controversially discussed with respect to the methodology. The aim of the present investigation was to compare three methods for determining interocclusal clearance during speech and in mandibular rest position.