Successful Defibrillation of Four Hypothermic Patients with Witnessed Cardiac Arrest.

Background: Because of the limited evidence available, recommendations for defibrillation of hypothermic patients vary among published guidelines.

Aim: To report successful defibrillation of four severely hypothermic patients with witnessed cardiac arrest.

Results: During a four-year period from 2014 to 2017, four of five hypothermic patients admitted to our institution with a history of sudden, unexpected ventricular fibrillation (core temperature: 24°C-27°C) were successfully defibrillated.

Outcome of avalanche victims with out-of-hospital cardiac arrest.

Study Background: Previous studies focused on the outcome of avalanche victims with out-of-hospital cardiac arrest (OHCA) after long duration of burial (>35min); the outcome of victims with short duration (≤35min) remains obscure.

Aim Of The Study: To investigate outcome of avalanche victims with OHCA.

Methods: Retrospective analysis of avalanche victims with OHCA between 2008 and 2013 in the Tyrolean Alps.

Is extracorporeal rewarming indicated in avalanche victims with unwitnessed hypothermic cardiorespiratory arrest?

International guidelines recommend using extracorporeal rewarming in all hypothermic avalanche victims with prolonged cardiac arrest if they have patent airways and a plasma potassium level≤12 mmol/L. The aim of this study was to evaluate outcome data to determine if available experience with extracorporeal rewarming of avalanche victims supports this recommendation. At Innsbruck Medical University Hospital, 28 patients with hypothermic cardiac arrest following an avalanche accident were resuscitated using extracorporeal circulation.

Age-related efficacy of parathyroid hormone on osseointegration in the rat.

Objective: Aging is a physiological determinant that can distinguish the outcome of a pharmaceutical therapy to improve osseointegration of titanium implants. Here we examined the possible interaction of intermittent parathyroid hormone (PTH) and the age of the recipient on the parameters of osseointegration in a rat tibia implantation model.

Material And Methods: Twenty female Wistar rats aged 8 months and 20 female rats aged 2 months received PTH at 60 microg/kg body weight or a vehicle by a subcutaneous injection three times a week.

Simultaneous in vivo comparison of bone substitutes in a guided bone regeneration model.

A direct, simultaneous comparison of bone substitutes is hampered by the limited number of samples that can be tested simultaneously. The goal of this study was to establish a preclinical model for guided bone regeneration that offers testing of different bone substitutes in a one-wall defect situation. We show here that up to eight titanium hemispheres can be placed on the calvaria of minipigs.

The anti-angiogenic substance TNP-470 impairs peri-implant bone formation: a pilot study in the rabbit metaphysis model.

Objectives: To study the osseointegration of dental implants under the conditions of impaired blood vessel formation in a rabbit model.

Material And Methods: Twenty-four titanium implants were placed in the diaphyses of 12 rabbits, two in each tibia. After 2 days, six animals received TNP-470, an anti-angiogenic substance, 10 mg/kg body weight, three times a week, by subcutaneous injection.

Age-related changes of cell outgrowth from rat calvarial and mandibular bone in vitro.

Aim: To establish whether within an autograft ageing has an impact on the number of cells capable of responding to growth and differentiation factors released at defect sites.

Material And Methods: The number of cells that grow out from calvarial and mandibular explants of rats 6 weeks and 9 months of age was evaluated and their response to mitogenic, chemotactic, and differentiation factors was characterized in vitro. The cell number was determined by automated counting, proliferation was evaluated by measuring the amount of (tritiated) (3)[H]thymidine incorporated into the DNA, and migration was assessed with the modified Boyden chamber assay.