Higher rate of cord-related adverse events in neonates with dry umbilical cord care compared to chlorhexidine powder. Results of a randomized controlled study to compare efficacy and safety of chlorhexidine powder versus dry care in umbilical cord care of the newborn.

Objective: Best practice for umbilical cord care (UC) still remains controversial in developed countries with aseptic perinatal care. A bicenter randomized clinical trial was performed to evaluate the efficacy of chlorhexidine (CX) powder versus dry cord care (DC) for UC.

Patients And Methods: All neonates of two neonatal care units were invited to take part in the study.

The influence of prelabor rupture of the membranes on the levels of oral mucosal immunoglobulins in the neonate.

Oral mucosal immunoglobulins play an important role in the human immune system as a first-line defense against viral and bacterial infection. Secretory immunoglobulin A (sIgA), IgD and the free secretory component (FSC) can be determined in the first days of life; however, it is yet unknown which events influence the local synthesis of the immunoglobulins. The aim of this study was to evaluate the influence of prelabor rupture of the membranes (PROM) within a period of 24 h on the synthesis of oral mucosal sIgA, IgD, FSC and albumin of neonates in their first day of life.

Natural history of serum immunoglobulin concentrations in low birth weight infants and association with respiratory tract infections.

Unlabelled: Infections are a significant cause of morbidity and mortality among low birth weight (LBW) infants.

The Aims Of Our Study Were: (1) to investigate whether serum antibody concentrations in 62 LBW infants (1,500-2,500 g) were normalized by 1 year of life, and (2) to determine the clinical relevance of humoral immaturity in these children during the 1st year compared to 20 appropriate-for-gestational-age (AGA) term infants. At 1 year of life, immunoglobulin serum concentrations in LBW infants were comparable to those of the control group.