Genotype-phenotype associations in Danish patients with ocular and oculocutaneous albinism.

Background: The study aimed to describe genotype-phenotype associations in patients with oculocutaneous and ocular-only albinism and to evaluate a set of diagnostic criteria proposed recently by Kruijt et al.

Materials And Methods: Genotype-phenotype associations in patients with a clinical diagnosis of albinism were studied based on imaging of hair and ocular features (nystagmus, iris color and translucency, fundus pigmentation and foveal development) and self-evaluated skin type. Patients were sub-grouped based on genetic findings.

Prefilled syringes for intravitreal injection reduce preparation time.

Introduction: The demand for intravitreal therapy has increased dramatically with the introduction of vascular endo-thelial growth factor inhibitors. Improved utilisation of existing resources is crucial to meeting the increased future demand. We investigated time spent preparing intravitreal injection treatment using either prefilled syringes or vials in routine clinical practice.

Axonal loss occurs early in dominant optic atrophy.

Purpose: This study set out to investigate retinal nerve fibre layer (RNFL) thickness and best corrected visual acuity (BCVA) in relation to age in healthy subjects and patients with OPA1 autosomal dominant optic atrophy (DOA).

Methods: We carried out a cross-sectional investigation of RNFL thickness and ganglion cell layer density in 30 healthy subjects and 10 patients with OPA1 DOA using optical coherence tomography (OCT). We then performed a regression analysis of RNFL thickness and BCVA versus age.

Surveillance for retinopathy of prematurity in a Danish country. Epidemiological experience over 20 years.

Purpose: An updated analysis of the trends in a Danish county regarding retinopathy of prematurity (ROP), outlining its natural history over the years 1982-2001.

Methods: Epidemiological data are given of the 132 infants in the county with birth years 1998-2001 prospectively under surveillance for ROP. The customary national screening limits of gestational age (GA) and birthweight (BW) of 32 weeks/1750 g were generally adhered to.

[Diabetic retinopathy in type 1 diabetics in the county of Frederiksborg].

Introduction: Screening for diabetic retinopathy in a Danish county--are we following the recommendations? Incidence and risk factors of development and progression of diabetic retinopathy and prevalence of blindness among type 1 diabetics consulting the hospital of Hillerød are being described.

Material And Methods: A total of 223 type 1 diabetics (debut < 30 years of age, insulin treated from first year of diagnosis) identified in a cross-sectional study in 1993 and followed until 2000 when data from last examination in the diabetes out-patient clinic and the ophthalmology clinic are registered.

Results: Ophthalmologists have screened nearly 97% of the patients as stated in the recommendations of the department.