Quality Assessment Framework of Clinical Routine Data for Secondary Use.

To systematically and comprehensively identify data issues in large clinical datasets, we adopted a harmonized data quality assessment framework with Python scripts before integrating the data into FHIR® for secondary use. We also added a preliminary step of categorizing data fields within the database scheme to facilitate the implementation of the data quality framework. As a result, we demonstrated the efficiency and comprehensiveness of detecting data issues using the framework.