Publications by authors named "Birgit D Rudolph"
Article Synopsis
- The study evaluated how well TP53 mutations and PSA levels predict tumor progression in prostate cancer patients.
- In a sample of 90 patients, 35.6% had TP53 mutations, which were linked to higher rates of tumor progression compared to those without mutations.
- TP53 mutations in specific regions (exon 7 and exon 8) were found to be more significant indicators of tumor recurrence than other factors like tumor stage or initial PSA levels.
Background: The predictive value of TP53 mutations and prostate-specific antigen (PSA) was assessed in prostate needle biopsies of samples without signs of malignancy for later affliction by prostate cancer (PCa). Comparison of mutation frequency and PSA level in prostate needle biopsies with data of patients with benign prostate hyperplasia (BPH) treated by transurethral resection (TURP), patients with prostatic intraepithelial neoplasia (PIN), and patients with PCa, was made.
Materials And Methods: A total of 466 samples were analysed from patients with benign and malignant diseases of the prostate, including 52 samples of needle biopsies of the prostate with repeated benign histopathological diagnosis.