ADEM is a common pediatric condition linked to MOG antibodies that results in brain growth impairment, but its specific impact from MOG antibodies was previously unclear.
The study included 62 MRI scans from 24 ADEM patients, revealing that both MOG-positive and negative patients initially had lower brain volumes compared to healthy controls.
Long-term results showed that MOG-negative patients experienced greater brain volume loss than MOG-positive ones, and relapsing MOG-positive patients also faced additional volume reductions.