Exploring Genetic Diversity for High CBD Content in Cannabis Accessions in Tropical and Subtropical Regions of India.

Cannabis, also known as marijuana or hemp, has been utilized since ancient times for industrial, religious, recreational, and medical uses. However, regardless of the intended use, there are legal requirements for quantitative testing of cannabinoids across the supply chains. This investigation aimed to evaluate the genetic diversity of 54 Cannabis samples collected from tropical and subtropical regions in India.

Optimizing agricultural sustainability: enriched organic formulations for growth, yield, and soil quality in a multi-crop system.

Utilizing agricultural and industrial wastes, potent reservoirs of nutrients, for nourishing the soil and crops through composting embodies a sustainable approach to waste management and organic agriculture. To investigate this, a 2-year field experiment was conducted at ICAR-IARI, New Delhi, focusing on a pigeon pea-vegetable mustard-okra cropping system. Seven nutrient sources were tested, including a control (T), 100% recommended dose of nitrogen (RDN) through farmyard manure (T), 100% RDN through improved rice residue compost (T), 100% RDN through a paddy husk ash (PHA)-based formulation (T), 75% RDN through PHA-based formulation (T), 100% RDN through a potato peel compost (PPC)-based formulation (T), and 75% RDN through PPC-based formulation (T).

Harnessing the power of native biocontrol agents against wilt disease of Pigeonpea incited by Fusarium udum.

Fusarium wilt, caused by (Fusarium udum Butler), is a significant threat to pigeonpea crops worldwide, leading to substantial yield losses. Traditional approaches like fungicides and resistant cultivars are not practical due to the persistent and evolving nature of the pathogen. Therefore, native biocontrol agents are considered to be more sustainable solution, as they adapt well to local soil and climatic conditions.

Genetic diversity and population structure of Fusarium udum in India and its correlation with pigeonpea wilt incidence.

In a study conducted in India, 50 Fusarium isolates were collected from pigeonpea growing regions and extensively examined for their cultural and morphological characteristics. These isolates exhibited significant variations in traits including growth rate, mycelial growth patterns, color, zonation, pigmentation, spore size, and septation. Subsequently, 30 isolates were chosen for pathogenicity testing on eight pigeonpea genotypes.

Molecular Characterization and Seasonal Variation in Expression of HSP70.1 Gene in Gangatiri Cattle and Its Comparison with Buffalo.

Under tropical climate heat stress is a major challenge for livestock production. HSP70.1 is a ubiquitously expressed protein maintaining cellular machinery through proper folding of denatured proteins and prevents cellular apoptosis and protect cell from heat stress.

A computational study on structural and functional consequences of nsSNPs in human dopa decarboxylase.

The Dopa Decarboxylase (DDC) gene plays an important role in the synthesis of biogenic amines such as dopamine, serotonin, and histamine. Non-synonymous single nucleotide polymorphisms (nsSNPs) in the DDC gene have been linked with various neurodegenerative disorders. In this study, a comprehensive analysis of nsSNPs in the DDC gene was conducted to assess their potential functional consequences and associations with disease outcomes.

Impact of induced mutation-derived genetic variability, genotype and varieties for quantitative and qualitative traits in species.

Purpose: The genus spp. is an aromatic herb from the family 'Lamiaceae'. It is extensively predominant in temperate and sub-temperate regions of the world.

Structure-based virtual screening of natural compounds against wild and mutant (R1155K, A1156T and D1168A) NS3-4A protease of Hepatitis C virus.

NS3-4A, a serine protease, is a primary target for drug development against Hepatitis C Virus (HCV). However, the effectiveness of potent next-generation protease inhibitors is limited by the emergence of mutations and resulting drug resistance. To address this, in this study a structure-based drug design approach is employed to screen a large library of 7320 natural compounds against both wild-type and mutant variants of NS3-4A protease.

Radio-frequency (RF) room temperature plasma treatment of sweet basil seeds ( L.) for germination potential enhancement by immaculation.

L. is an antiviral and immunity boosting medicinal plant and culinary herb. Potential use of sweet basils in COVID 19 prevention and management is making its demand rise.

Origin of metamagnetism in skyrmion host Cu[Formula: see text]OSeO[Formula: see text].

Skyrmion host chiral Cu[Formula: see text]OSeO[Formula: see text] has attracted researchers due to several intriguing properties. Observation of metamagnetism in low-temperature and low-field makes the magnetic properties of Cu[Formula: see text]OSeO[Formula: see text] more complex. Here, we present an investigation on metamagnetism in Cu[Formula: see text]OSeO[Formula: see text] by analyzing its structural and magnetic properties.

Different Critical Exponents on Two Sides of a Transition: Observation of Crossover from Ising to Heisenberg Exchange in Skyrmion Host Cu_{2}OSeO_{3}.

We present experimental investigation on critical phenomena in Cu_{2}OSeO_{3} by analyzing the critical behavior of magnetization using a new method. This is necessary as a crossover from 3D Ising to 3D Heisenberg has been observed in Cu_{2}OSeO_{3}. The proposed method is applicable to explore the physics for a wide range of materials showing trivial or nontrivial critical behavior on two sides of the transition.

Quantification of genetic variability and stable genotype selection over the years in the germplasm of critically endangered Prishanparni (Uraria picta Desv.).

Prishanparni (Uraria picta Desv.), a critically endangered annual shrub belonging to the family 'Papillionaceae'. It is widely distributed throughout India, Sri Lanka, Bangladesh, Tropical Africa, Malay Islands, and the Philippines.

Multiple magnetic phase transitions with different universality classes in bilayer La[Formula: see text]Sr[Formula: see text]Mn[Formula: see text]O[Formula: see text] manganite.

Here, we report three magnetic transitions at 101 K (T[Formula: see text]), 246 K (T[Formula: see text]) and 295 K (T[Formula: see text]) in bilayer La[Formula: see text]Sr[Formula: see text]Mn[Formula: see text]O[Formula: see text]. The second order phase transitions have been identified at these transition points with the help of change in entropy analysis and modified Arrott plots (MAPs). The critical behavior around T[Formula: see text], T[Formula: see text] and T[Formula: see text] have been studied by MAPs and Kouvel-Fisher method.

Computational screening of natural compounds from R. Br. for inhibition of SARS-CoV-2 main protease.

Unlabelled: The novel Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) has emerged to be the reason behind the COVID-19 pandemic. It was discovered in Wuhan, China and then began spreading around the world, impacting the health of millions. Efforts for treatment have been hampered as there are no antiviral drugs that are effective against this virus.

Ligand-based design approach of potential Bcl-2 inhibitors for cancer chemotherapy.

Background And Objectives: Overexpression of prosurvival Bcl-2 family members make tumor cells resistant to conventional cancer therapeutic agents. It is commonly observed feature in many different types of human tumors. Hence, small-molecules as Bcl-2 inhibitors may have a promising therapeutic potential for the treatment of human cancer.

Magnetism in quasi-two-dimensional tri-layer LaSrMnO manganite.

The tri-layer La[Formula: see text]Sr[Formula: see text]Mn[Formula: see text]O[Formula: see text] manganites of Ruddlesden-Popper (RP) series are naturally arranged layered structure with alternate stacking of ω-MnO[Formula: see text] (ω = 3) planes and rock-salt type block layers (La, Sr)[Formula: see text]O[Formula: see text] along c-axis. The dimensionality of the RP series manganites depends on the number of perovskite layers and significantly affects the magnetic and transport properties of the system. Generally, when a ferromagnetic material undergoes a magnetic phase transition from ferromagnetic to paramagnetic state, the magnetic moment of the system becomes zero above the transition temperature (T[Formula: see text]).

Effect of ozone application on the removal of pesticides from grapes and green bell peppers and changes in their nutraceutical quality.

The present study evaluates the efficacy of ozonated water for the removal of pesticide residues in grapes and green bell peppers. Fruit fortified with pesticides (azoxystrobin, chlorothalonil, chlorpyrifos, cypermethrin, hexaconazole and methyl parathion) were subjected to 15 and 30 min aqueous ozone treatment. GC analysis of ozonated fruits showed a 48.

Screening of natural compounds from Cyperus rotundus Linn against SARS-CoV-2 main protease (M): An integrated computational approach.

Coronavirus disease 2019 (COVID-19) is a viral respiratory disease that has been spreading across the globe. The World Health Organization (WHO) declared it as a public health emergency. The treatment of COVID-19 has been hampered due to the lack of effective therapeutic efforts.

Structure-based design approach of potential BCL-2 inhibitors for cancer chemotherapy.

B-cell lymphoma 2 (BCL-2) family is one of the chief regulators of cellular apoptosis. The intricate interactions between pro-apoptotic and anti-apoptotic genes of the BCL-2 family dictate the apoptotic balance of the cell. An overexpression of the anti-apoptotic members of BCL-2 is indicative of cell death evasion and cancer metastasis.

screening of therapeutic potentials from against the dimeric main protease (M) structure of SARS-CoV-2.

The novel coronavirus also referred to as SARS-CoV-2 causes COVID-19 and became global epidemic since its initial outbreak in Wuhan, China, in December 2019. Research efforts are still been endeavoured towards discovering/designing of potential drugs and vaccines against this virus. In the present studies, we have contributed to the development of a drug based on natural products to combat the newly emerged and life-threatening disease.

Gamma irradiation-induced variability in morpho-agronomic and oil quality traits of L.

Purpose: To develop elite mutant in having morphotype and oil content of , and oil quality of .

Materials And Methods: The dormant runner of menthol rich genotype MPK-5 were subjected to different doses of γ- irradiation (10, 20, 30, 50, 70, 90, and 110 Gy) at a dose rate of 55 Gy/min to induce the genetic variability for herb and oil yield as well as oil quality. A wide spectrum of variability for agro-morphological traits, herb yield, and quality profile was observed among the mutants.

Cost effective liquid phase exfoliation of MoS nanosheets and photocatalytic activity for wastewater treatment enforced by visible light.

Scalable production of high-quality MoS nanosheets remains challenging for industrial applications and research in basic sciences. N-methyl-2pyrrolidine (NMP) is a commonly used solvent for exfoliation of MoS nanosheets having further disadvantage of slow volatility rate. The present study demonstrates a cost-effective facile chemical route to synthesize few-layer MoS nanosheets using acetone as a solvent and by varying bulk initial concentration of samples to scale up the production in large scale to fulfill the demand for potential applications.

Investigating genetic variability in Hsp70 gene-5'-fragment and its association with thermotolerance in Murrah buffalo (Bubalus bubalis) under sub-tropical climate of India.

The present study was undertaken to investigate genetic variability in a fragment comprising 5'UTR along with partial coding sequence of Hsp70 gene and its association with thermotolerance traits in Murrah buffalo at ICAR-Research Complex for Eastern Region, Patna (India). The allelic variants were identified from genomic DNA samples using SSCP technique. The PCR products were sequenced and analyzed.

3D-Ising like ferromagnetism in skyrmionic-bubbles host infinite-layer LaSrMnO manganite perovskite.

The critical behavior of infinite-layer LaSrMnO of Ruddlesden-Popper series manganite has been studied around the transition temperature ([Formula: see text]). To reveal the universality class that explains the critical behavior in LaSrMnO several methods, such as modified Arrott plots, Kouvel-Fisher, entropy and critical isotherm analysis have been employed. The critical exponent [Formula: see text] for infinite-layer is obtained independently from critical magnetization isotherm and found to satisfy the Widom scaling relation [Formula: see text].