Publications by authors named "Bircan Kolbası"
Article Synopsis
- * Twenty-eight male rats were divided into four groups to analyze sperm parameters, testicular tissue histology, and biochemical markers related to oxidative stress and blood-testis barrier function.
- * Results showed that both ADMSC-CM injection and varicocelectomy improved sperm quality and decreased oxidative stress without a significant difference in preserving testicular histology, indicating that ADMSC-CM could be a promising treatment method for varicocele.
This study aimed to investigate the effects of the calpain inhibitor N-Acetyl-Leu-Leu-norleucinal (ALLN) on neuroapoptotic cell damage caused by Copper Oxide Nanoparticles (CuO-NP) and exacerbation of damage through brain ischemia/reperfusion (I/R) in a rat model. Male Wistar Albino rats (n=80) were divided into eight groups: Control, I/R, CuO-NP, CuO-NP+I/R, I/R+ALLN, CuO-NP+ALLN, CuO-NP+I/R+ALLN, and DMSO. Biochemical markers (MBP, S100B, NEFL, NSE, BCL-2, Cyt-C, Calpain, TNF-α, Caspase-3, MDA, and CAT) were measured in serum and brain tissue samples.
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- This systematic review and meta-analysis investigates whether varicocele repair (VR) can lower sperm DNA fragmentation (SDF) and seminal oxidative stress (measured by malondialdehyde or MDA) in infertile men.
- An analysis of 29 studies involving 1,491 men shows a significant reduction in SDF post-VR, regardless of the surgical technique used and the method of SDF testing.
- The findings also indicate a notable decrease in seminal MDA levels following VR, supporting the effectiveness of varicocele repair in improving reproductive parameters in affected men.
Background: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects.
View Article and Find Full Text PDFObjective: Increasing evidence shows that three dimensional cell culture models better reflect the in vivo tumor microenvironment than two dimensional cell culture models. Co-culture models are ideal cell culture models for understanding the communication between cells and the in vivo microenvironment. Changes in expression levels of E-cadherin are closely related to cancer metastasis and progression.
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- - The study investigates the impact of chronic unpredictable stress (CUS) on the blood-testis barrier (BTB) and sperm quality in C57Bl/6 mice by comparing a stress group to a non-treated control group.
- - Results showed that CUS led to increased oxidative stress markers, reduced testosterone levels, and damage to BTB integrity, as evidenced by histopathological evaluations and changes in key BTB proteins ZO-1 and CLDN11.
- - Although total sperm concentration and motility remained unchanged, CUS significantly decreased progressive motility, sperm morphology, chromatin integrity, and acrosomal reaction rates, indicating that chronic stress negatively affects sperm quality.
Purpose Radiotherapy, chemotherapy, various tumors and invasive surgery can result in ejaculatory dysfunction and testicular insufficiency. Sperm cryopreservation is the only method which can provide a baby for couples. Cryopreservation freezes tissues and cells, allowing them to be stored for future use by stopping all biological activities.
View Article and Find Full Text PDFIntroduction: Peripheral nerve injuries are encountered frequently in clinical practice. In nerve repair, an end-to-end suture is the preferable choice of treatment. However, where primary closure is not possible, the defect is to be repaired with a nerve graft.
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