Fe(III)-catalyzed -selective C-H bond chalcogenation of phenols.

An efficient, eco-friendly, and scalable protocol has been introduced for the -selective C-X (X = Se/S) bond formation of phenols employing earth-abundant, less-toxic Fe(III)-catalysts and the green solvent ethanol without using any directing template, stabilizing ligands, oxidants, or additives. The key attraction lies in the impressive -selectivity with moderate to good yields, wide functional group compatibility under mild aerobic reaction conditions, and the synthetic modification of the products towards value-added molecules.

Copper-Catalyzed Regioselective Remote C-H Bond Chalcogenation of Aromatic Amine Derivatives without Using Any Large Template.

A mild and convenient strategy has been developed for the -selective chalcogenation of anilide scaffolds via C-H bond functionalization. This methodology employs one of the most earth-abundant and inexpensive Cu(II) catalysts and a commercially available simple aryl chalcogen source without any complex directing template, exogenous ligand, acid/base, oxidant, or other additives. The key feature of this methodology is an impressive regioselectivity along with a wide range of functional group tolerance with good to excellent yields under aerobic conditions.

Redox-active alkylsulfones as precursors for alkyl radicals under photoredox catalysis.

A method for generating alkyl radicals using visible-light photoredox catalysis is described. This procedure was found to present an efficient means to access a diverse collection of 1°, 2°, and 3° alkyl radicals through the single-electron transfer of sulfones under mild reaction conditions. These alkyl radicals generated the reductive desulfonylation of readily synthesized and stable alkylsulfones were engaged to forge C-C bonds.