Publications by authors named "Bipin P Savani"
Post-transplant cyclophosphamide (PTCY) is increasingly used as effective graft-versus-host disease (GvHD) prophylaxis in allogeneic hematopoietic-cell transplantation (allo-HCT). However, PTCY is associated with toxicities. Whether patients with specific comorbidities are more vulnerable to cyclophosphamide-induced toxicity is unclear.
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- Researchers evaluated the transplant conditioning intensity (TCI) score on a group of 4060 patients with acute myeloid leukemia who underwent allogeneic hematopoietic cell transplantation between 2018 and 2021.
- Patients were categorized into three TCI categories (low, intermediate, high) based on their scores, allowing assessment of the TCI's ability to predict outcomes like non-relapse mortality and relapse risk.
- Results showed that the TCI score effectively stratified patients by risk, demonstrating its relevance in predicting complications associated with transplant conditioning regimens.