Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: histological, biochemical and immunological perspectives.

We have evaluated the toxicity profile of a unique immunomodulator, neem leaf glycoprotein (NLGP) on different physiological systems of Swiss mice and Sprague Dawley rats. NLGP injection, even in higher doses than effective concentration caused no behavioral changes in animals and no death. NLGP injection increased the body weights of mice slightly without any change in organ weights.

Inhibition of subcutaneous growth of Ehrlich ascites carcinoma (EAC) tumor by post-immunization with EAC-cell gangliosides and its anti-idiotype antibody in relation to tumor angiogenesis, apoptosis, cell cycle and infiltration of CD4+, CD8+ lymphocytes, NK cells, suppressor cells and APC-cells in tumor.

Both EAC-tumor associated gangliosides and its anti-idiotype antibody inhibited growth of this tumor significantly. Immuno-histological studies with von Willebrand Factor (vWF) antibody indicated that tumor angiogenesis as determined by expression of vWF decreased in tumors of mice, post-immunized with EAC-cell gangliosides as well as its anti-idiotype antibody. Infiltration of various immune cells of the host in the tumor correlated to some extent with tumor-growth inhibition.

Effect of organic forms of phosphorus and variable concentrations of sulfide on the metabolic generation of soluble-reactive phosphate by sulfur chemolithoautotrophs: a laboratory study.

In aquatic systems, recycling of phosphorus (P) is strongly influenced by microbial metabolic responses. This study was designed to look at the generation of P (as soluble-reactive phosphate (SRP)) from organic P-enriched sediments by benthic sulfur chemolithoautotrophs. The study revealed that microbial density was greater in organic P-enriched sediments when compared to sediments without added organic P and the presence of organic P significantly influenced mobilization of SRP from sediment.