Publications by authors named "Binzhao Chen"
Maintenance of proteome integrity is essential for cell function and survival in changing cellular and environmental conditions. The endoplasmic reticulum (ER) is the major site for the synthesis of secretory and membrane proteins. However, the accumulation of unfolded or misfolded proteins can perturb ER protein homeostasis, leading to ER stress and compromising cellular function.
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- The biosynthesis of C sterols from squalene involves the C24-alkylation process and the removal of three methyl groups, notably two from the C4 position.
- A bifunctional enzyme called 3β-hydroxysteroid dehydrogenase/C4-decarboxylase (3βHSD/D) is essential for two specific demethylation reactions that impact growth and can lead to disorders in humans and yeast.
- Using CRISPR/Cas9, researchers created knockout mutants in Arabidopsis to study two genes, discovering that these genes are crucial for male gametogenesis and embryogenesis, as their loss leads to pollen lethality.