Synopsis of recent research by authors named "Binzhang Shen"
- Binzhang Shen's recent research primarily focuses on synthetic lethality in cancer, exploring novel therapeutic targets in cancer cells with specific genetic vulnerabilities, such as BRCA1/2 mutations.
- His studies employ CRISPR-Cas9 screening and characterize the molecular interactions, such as the role of deubiquitinating enzyme USP1, which shows potential for targeting DNA damage repair mechanisms in cancer therapy.
- Additionally, Shen investigates enhancing T cell function in the context of immunotherapy, with an emphasis on modulating T cell metabolism in solid tumor microenvironments and has also contributed to antibiotic-free treatments in poultry health.
