Publications by authors named "Binyin Shi"
Integrins have been suggested to be involved in SARS-CoV-2 infection, but the underlying mechanisms remain largely unclear. This study aimed to investigate how integrins facilitate the ACE2-mediated cellular entry of SARS-CoV-2. We first tested the susceptibility of a panel of human cell lines to SARS-CoV-2 infection using the spike protein pseudotyped virus assay and examined the expression levels of integrins in these cell lines by qPCR, western blot and flow cytometry.
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- Human genomics is shifting from a single reference sequence to a more inclusive pangenome, but populations of Asian ancestry remain underrepresented.
- The Chinese Pangenome Consortium has released data from 116 high-quality genome assemblies based on 58 samples from various minority ethnic groups in China, significantly enhancing existing genomic references.
- Their findings reveal millions of novel genetic variants, particularly in underrepresented populations, highlighting the potential for discoveries related to human evolution and disease genetics.
Background And Purpose: With the progressive increase in the prevalence of type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN) - one of the most common chronic microvascular complications - has evolved into a significant cause of death worldwide among end-stage renal disease patients. Academic researchers have for decades focused on the development of DN and recently found that free fatty acids (FFAs) constituted an independent risk factor for vascular complications in T2DM patients. It is therefore critical to determine whether the metabolic profile of FFAs is related to DN.
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