The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice.

Elevated plasma levels of low-density lipoprotein-C (LDL-C) increase the risk of atherosclerotic cardiovascular disease. Circulating LDL is derived from very low-density lipoprotein (VLDL) metabolism and cleared by LDL receptor (LDLR). We have previously demonstrated that cargo receptor Surfeit 4 (Surf4) mediates VLDL secretion.

Systemic effects of ingested Lactobacillus rhamnosus: inhibition of mast cell membrane potassium (IKCa) current and degranulation.

Exposure of the intestine to certain strains lactobacillus can have systemic immune effects that include the attenuation of allergic responses. Despite the central role of mast cells in allergic disease little is known about the effect of lactobacilli on the function of these cells. To address this we assessed changes in rat mast cell activation following oral treatment with a strain of Lactobacillus known to attenuate allergic responses in animal models.

[Advance in study on active protein and peptide produced by marine bacteria--a review].

Biological active resources are various and abundant in the ocean. With this realization, active proteins and peptides especially marine bacteria active proteins and peptides have attracted much attention recently. The achievements in the study of bioactivities of marine bacterial proteins and peptides were reviewed in this paper.

[Isolation and purification of ribosome-inactivating proteins from bitter melon seeds by ion exchange chromatographic columns in series].

An anion exchange chromatographic column (DEAE-650C) and a cation exchange chromatographic column (CM-650C) were connected in series on a perfusion chromatography workstation. The crude extract of bitter melon seeds flowed through the two columns and the unadsorbed fraction on the DEAE-650C column was then directly readsorbed on the CM-650C column. Two protein components with antifungal activity were eluted from the cation exchange chromatographic column by linear salt gradient.