Publications by authors named "Binu B Philips"
Article Synopsis
- The incidence of infective endocarditis (IE) in the U.S. rose from 10.2 to 14.4 cases per 100,000 population from 1990 to 2019, with men experiencing a greater increase than women.
- The rise was particularly notable among those aged 55 and older, while the incidence among young individuals aged 5 to 19 decreased by 36.6% over the same period.
- Regional differences were significant, with Utah seeing the highest increase (66.2%) in ASIR, while California had the smallest rise (30.2%), and overall mortality from IE increased by 126% in the U.S. compared to a global increase of 19.6%.
Cardiac resynchronization therapy (CRT) can improve heart function and decrease arrhythmic events. We tested whether CRT altered circulating markers of calcium handling and sudden death risk. Circulating cardiac sodium channel messenger RNA (mRNA) splicing variants indicate arrhythmic risk, and a reduction in sarco/endoplasmic reticulum calcium adenosine triphosphatase 2a (SERCA2a) is thought to diminish contractility in heart failure.
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