RasGRP4 aggravates ischemia-reperfusion injury in diabetic kidneys by mediating communication between macrophages and T cells.

Diabetes mellitus (DM) is acknowledged as an independent risk factor for acute kidney injury. Ras guanine nucleotide-releasing protein-4 (RasGRP4) exerts a notable role in modulating immune-inflammatory responses and kidney disease progression in diabetes. Herein, we delved into the specific role and mechanism of RasGRP4 in diabetic renal ischemia-reperfusion injury.

Exploring the clinical value of direct anterior approach THA for short-term hip function improvement: A single-center retrospective analysis of short-term outcomes.

To investigate the outcomes of the direct anterior approach (DAA) in total hip arthroplasty (THA) and its impact on improving hip joint function. This retrospective analysis included 94 patients who underwent THA between December 2017 and December 2020 at Dongguan Hospital, Guangzhou University of Chinese Medicine. The study group comprised 50 patients who received the DAA, while the control group comprised 44 patients who received the postero-lateral approach (PA).

Role of comprehensive geriatric assessment in screening for mild cognitive disorders.

Background: The role of comprehensive geriatric assessment (CGA) in screening for mild cognitive disorders was not known.

Aim: To evaluate the role of CGA in screening for mild cognitive disorders.

Methods: A total of 100 elderly people who underwent health examinations in our hospital and community between January 2020 and December 2021 were included for analysis.

Thrombotic microangiopathy mediates poor prognosis among lupus nephritis complement lectin and alternative pathway activation.

Objective: The pathogenesis of thrombotic microangiopathy (TMA) in lupus nephritis (LN) remains complicated. This study aimed to detect the deposition of complement lectin pathway (LP) and alternative pathway (AP) components in renal tissues, then evaluate the clinicopathological characteristics and risk factors for renal survival between patients with or without TMA in LN cohorts.

Methods: We included 79 patients with biopsy-proven LN-associated TMA and matched the same number of LN patients without TMA as the control group.