Synthesis, Insecticidal Activities, and Structure-Activity Relationship of Phenylpyrazole Derivatives Containing a Fluoro-Substituted Benzene Moiety.

Fluorinated organic compounds represent a growing and important family of commercial chemicals. Introduction of fluorine into active ingredients has become an effective way to develop modern crop protection products. Given the particular properties of fluorine and high efficiency and selectivity of diamide insecticides, we designed and synthesized 27 anthranilic diamides analogues containing fluoro-sustituted phenylpyrazole.

Eutectics and Salt of Dapsone With Hydroxybenzoic Acids: Binary Phase Diagrams, Characterization and Evaluation.

Poor solubility and low dissolution rate of pharmaceuticals in many cases largely limit their bioavailability and efficacy. One of the promising approaches to improve dissolution behavior is to develop new multicomponent solid forms. Herein we use this strategy to synthesize new multicomponent solids of dapsone (DAP), which belongs to BCS class IV, with a series of hydroxybenzoic acid coformers.