Bioinformatics analysis of miRNAs germacrone protection on diabetic nephropathy.

Diabetes nephropathy (DN) is a prevalent and severe microvascular diabetic complication. Despite the recent developments in germacrone-based therapies for DN, the underlying mechanisms of germacrone in DN remain poorly understood. This study used comprehensive bioinformatics analysis to identify critical microRNAs (miRNAs) and the potential underlying pathways related to germacrone activities.

An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4.

: Ischemia-reperfusion-induced acute kidney injury (IR-AKI), characterized by the abrupt decline in renal function, is distinguished by the intricate interplay between oxidative stress and inflammation. In this study, a reactive oxygen species (ROS) scavenger-CF@PDA was developed to effectively target antioxidant and anti-inflammatory pathways to disrupt the oxidative stress-inflammation cycle in IR-AKI. : UV-vis absorption spectra, FTIR spectra, and TEM were employed to determine the successful construction of CF@P.

Comprehensive analysis to identify PUS7 as a prognostic biomarker from pan-cancer analysis to osteosarcoma validation.

Aim: Pseudouridylation has demonstrated the potential to control the development of numerous malignancies. PUS7(Pseudouridine Synthase 7) is one of the pseudouridine synthases, but the literature on this enzyme is limited to several cancer types. Currently, no investigation has been performed on the systematic pan-cancer analysis concerning PUS7 role in cancer diagnosis and prognosis.

Structure and properties variations of regenerated cellulose fibers induced by metal ion impurity.

In the ionic liquids (ILs) method for processing regenerated cellulose fiber (RCF), which is a high-performance ecologically benign product, metal ion impurities (such as Fe and Cu) of cellulose might inevitably remain in the recycled ILs and coagulation bath. The presence of metal ions might negatively impact the properties of the manufactured RCFs and obstruct their applications, which are urgent to be made clear. For this research, the solvent for dissolving wood pulp cellulose (WPC) was 1-ethyl-3-methylimidazolium diethyl phosphate ([Emim]DEP) with various metal ion concentrations.

Effects of Glucose and Coagulant on the Structure and Properties of Regenerated Cellulose Fibers.

Regenerated cellulose fiber (RCF) is an environmentally friendly material with outstanding mechanical properties and recyclability, which has been used in a large number of applications. However, during the spinning process using ionic liquids (ILs) as solvents, the dissolved cellulose continues to degrade and even produces degradation products such as glucose, which can enter the recycled solvent and coagulation bath. The presence of glucose can seriously affect the performance of the produced RCFs and hinder their applications, so it has become critical to clarify the regulation and mechanism of this process.

Effects of coagulating conditions on the crystallinity, orientation and mechanical properties of regenerated cellulose fibers.

Fabricating regenerated cellulose fibers using ionic liquids is a novel and green technology. Structural changes of regenerated fibers during forming process affect the macroscopic properties of regenerated fibers. The study of the regenerated fiber forming mechanisms in conditions relevant to fiber spinning processes, especially in the process of dry-wet spinning, is necessary and meaningful.

The Role of Ferroptosis in Acute Kidney Injury.

Ferroptosis is a novel cell death method discovered in recent years. It is usually accompanied by massive accumulations of iron and lipid peroxidation during cell death. Recent studies have shown that ferroptosis is closely associated with the pathophysiological processes of many diseases, such as tumors, neurological diseases, localized ischemia-reperfusion injury, kidney injury, and hematological diseases.

Synthesis of alkyl polyglycosides using SOH-functionalized ionic liquids as catalysts.

An effective process for synthesis of alkyl polyglycosides (APG) was developed using SOH-functionalized ionic liquids (SFILs) as catalysts. Four SFILs, [PSmim][HSO], [PSmim][TSA], [PSPy][HSO] and [PSPy][TSA], were designed and synthesized for APG synthesis. The results indicated that [PSmim][HSO] shows the best catalytic performance among these four SFILs, which has a great agreement with the order of their acidities.

Development and Validation of a Nomogram for Preoperative Prediction of Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma and Type 2 Diabetes Mellitus.

Purpose: To develop and validate a nomogram to predict central compartment lymph node metastasis in PTC patients with Type 2 Diabetes.

Patients And Methods: The total number of enrolled patients was 456. The optimal cut-off values of continuous variables were obtained by ROC curve analysis.