Publications by authors named "Binli Wen"
Article Synopsis
- * The lncRNA KB-1460A1.5 functions as a tumor suppressor by promoting ferroptosis in glioma cells, enhancing their sensitivity to ferroptosis inducers like RSL3.
- * The study indicates that KB-1460A1.5 reduces certain fatty acid levels and inhibits a specific signaling pathway, leading to decreased tumor growth in animal models, suggesting its potential as a therapeutic target.
Background: In our previous study, we found for the first time that temozolomide (TMZ), the first-line chemotherapeutic agent for glioblastoma (GBM), can generate a large amount of reactive oxygen species (ROS) under ultrasound irradiation. Sonodynamic therapy (SDT) using TMZ as the sonosensitizer produced more potent antitumor effects than TMZ alone. Here, we further evaluate the effects of TMZ-based SDT on subcellular structures and investigate the immunogenic cell death (ICD)-inducing capability of TMZ-based SDT.
View Article and Find Full Text PDFTemozolomide (TMZ) has been determined to be the chemotherapeutic drug with efficacy for glioblastoma (GBM). Thus, potentiating the therapeutic effect of TMZ can undoubtedly yield twice the result with half the effort. In this study, we found for the first time that TMZ can produce reactive oxygen species (ROS) under the influence of ultrasound (US).
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