Publications by authors named "Binkai Liu"
Article Synopsis
- The study aimed to explore how different types of chocolate consumption (dark, milk, and total chocolate) affect the risk of developing type 2 diabetes (T2D) among participants in three major US health studies.
- It included over 192,000 participants who were initially free of T2D and monitored for several years, collecting data on their chocolate intake and T2D incidence.
- Results indicated that those consuming 5 or more servings of dark chocolate weekly had a 21% lower risk of developing T2D, while total chocolate consumption suggested a 10% risk reduction, but no significant benefits were found for milk chocolate.
Article Synopsis
- Lignans are natural compounds found in many Western diets, thought to potentially lower the risk of developing type 2 diabetes (T2D).
- This study analyzed data from over 201,000 participants across multiple health studies to explore the relationship between lignan intake and T2D incidence over several decades.
- Results indicated that higher lignan consumption was linked to a lower risk of T2D, showing particular promise except for one type, lariciresinol, with the highest versus lowest quintile of intake yielding a hazard ratio of 0.87.
Article Synopsis
- * This technique involves intermolecular electron transfer that produces charged radicals, which can oxidize important cellular coenzymes and generate reactive superoxide radicals.
- * Our best Type-I photodynamic agent can self-assemble in water, effectively target the endoplasmic reticulum, and shows strong antitumor activity even in low-oxygen conditions, with an IC of 0.96 μM in HeLa tumor models.
Bacterial multi-drug resistance has become a concern worldwide, especially after the emergence of carbapenemases. Adjuvants with antibacterial potentiation activity can resensitise drug-resistant strains to carbapenems. However, only a few adjuvants with antibacterial potentiation activity are currently available in clinical practice.
View Article and Find Full Text PDFImportance: The associations of low-carbohydrate diets (LCDs) with long-term weight management remains unclear, and the source and quality of macronutrients within LCDs are less explored.
Objectives: To prospectively examine associations between changes in LCD indices and weight change among US adults.
Design, Setting, And Participants: This prospective cohort study included initially healthy participants at baseline from the Nurses' Health Study (NHS; 1986-2010), Nurses' Health Study II (NHSII; 1991-2015), and Health Professionals Follow-up Study (HPFS; 1986-2018).
Background: Phytosterols are structurally similar to cholesterol and partially inhibit intestinal absorption of cholesterol, although their impact on coronary artery disease (CAD) risk remains to be elucidated.
Objectives: This study aimed to prospectively assess the associations between total and individual phytosterol intake and CAD risk in United States health professionals.
Methods: The analysis included 213,992 participants from 3 prospective cohorts-the Nurses' Health Study (NHS), NHSII, and Health Professionals Follow-Up Study-without cardiovascular disease or cancer at baseline.
Background: Plant-based dietary patterns are gaining more attention due to their potential in reducing the risk of developing major chronic diseases, including type 2 diabetes (T2D), cardiovascular disease (CVD), cancer, and mortality, while an up-to-date comprehensive quantitative review is lacking. This study aimed to summarize the existing prospective observational evidence on associations between adherence to plant-based dietary patterns and chronic disease outcomes.
Methods: We conducted a systematic review and meta-analysis of evidence across prospective observational studies.
Background: Associations between per- and polyfluoroalkyl substances (PFAS) and blood lipid levels in humans were mixed.
Objectives: The objective of this meta-analysis was to summarize associations between PFAS and blood lipids in adults.
Methods: A literature search was conducted on PubMed and Web of Science for articles published through 13 May 2022 that examined associations between PFAS and blood lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triacylglycerols (TGs).
Low diet quality is a significant public health problem in the United States, especially among low-income populations. The food environment influences dietary choices. When applied to eating behavior, behavioral economics (BE) recognizes that decision biases instigated by a food environment saturated with unhealthy foods may lead people to purchase such foods, even when they possess the necessary information and skills to make healthy dietary choices.
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- Histone deacetylase 6 (HDAC6) plays key roles in various cellular functions like protein stability and cell movement, prompting the development of selective inhibitors to study its functions.
- Traditional genetic methods like CRISPR and siRNA have limitations, leading to the exploration of PROTAC technology, which can effectively eliminate entire proteins from cells for research purposes.
- The authors present new HDAC6-selective degraders using Von Hippel-Lindau (VHL) E3 ubiquitin ligase, showing promising degradation capabilities in two cell lines, which could enhance the study of HDAC6 and its related cellular pathways without interference from other substrates.
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor involved in multiple biological processes including immune cell differentiation, intestinal function and inflammation. Based on the scaffold of naturally occurring AhR ligand 6-formylindolo (3,2-b) carbazole (FICZ, 2), a series of analogues has been designed, synthesized and evaluated by cell-based assays. The structure-activity relationships study has successfully led to the discovery of compound 11e with extremely potent activity.
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