GRIK3 deficiency promotes non-small cell lung cancer progression by the regulation of the UBE2C/CDK1/Wnt signaling pathway.

Glutamate ionotropic receptor kainate type subunit 3 (GRIK3) is a predominant excitatory neurotransmitter receptor in the mammalian brain. While it is known that GRIK3 is involved in normal neurophysiologic processes, its biological functions in tumor progression are still poorly understood due to limited investigation. In this study, we reported for the first time that GRIK3 expression was downregulated in non-small cell lung cancer (NSCLC) tissues as compared to paracarcinoma tissues.

Using a mixed method to identify communication skills training priorities for Chinese general practitioners in diabetes care.

Background: In China diabetes care is gradually shifting from secondary to primary care with great infrastructure investment and GP training. However, most GPs in China lack communication skills training, which is a huge obstacle in communication with their patients in primary care. In this study we seek to identify training priorities that is evidence-based, appropriate for the context of primary care in China, and that meet the real needs of both GPs and people with diabetes.

Genomic features of Chinese small cell lung cancer.

Background: Small cell lung cancer (SCLC) is an aggressive disease with poor survival. Although molecular and clinical characteristics have been established for SCLC in western patients, limited investigation has been performed for Chinese SCLC patients.

Objective: In this study, we investigated the genomic features of Chinese SCLC patients.

Failure Analysis of Hat-Stringer-Stiffened Aircraft Composite Panels under Four-Point Bending Loading.

Hat-stringer-stiffened composite panels have been widely used in aircrafts. Accurate failure analysis of them is important for the safety and integrity of the fuselage. During the service period, these panels will bear not only the lateral force caused by the bending of fuselage, but also the radial pressure caused by the internal and external differential pressure during the take-off and landing of the aircraft.

A Two-Dimensional Model for Pin-Load Distribution and Failure Analysis of Composite Bolted Joints.

Multibolt composite joints are widely used in aircraft structures. The determination of the pin-load distribution among the bolts is a critical step in the failure prediction of bolted joints. In this paper, a two-dimensional model of the multibolt composite structure is established for the pin-load distribution analysis.

[Diagnostic values of the clinical characteristics of chronic cough].

Objective: To evaluate whether the clinical characteristics of chronic cough were helpful in determining its specific causes.

Methods: Patients with chronic cough were evaluated by a validated systematic diagnostic protocol. The patients with identified single cause were divided into 4 groups accordingly: cough-variant asthma (CVA), upper airway cough syndrome (UACS) or post-nasal drip syndrome (PNDS), eosinophilic bronchitis (EB), gastroesophageal reflux related cough (GERC), and the characteristics of the timing, character, onset and associated manifestations of chronic cough in different causes were compared.