Influence of silver doping on pro-inflammatory and pro-fibrogenic effects of nano-titanium dioxide in murine lung.

Silver is usually loaded on nano-titanium dioxide (TiO ) through photodeposition method to enhance visible-light catalytic functions for environment purification. However, little is known about how the toxicity changes after silver doping and how the physicochemical properties of loaded components affect nanocomposite toxicity. In this study, Ag-TiO with different sizes and contents of silver particles were obtained by controlling photodeposition time (PDT) and silver addition amount.

Toxicity mechanism of nanomaterials: Focus on endoplasmic reticulum stress.

Over the years, although the broad application of nanomaterials has not brought convenience to people's life, growing concern surrounds their safety. Recently, much emphasis has been placed on exploring the toxicity mechanism of nanoparticles. Currently established toxic mechanisms include oxidative stress, inflammatory response, autophagy, and DNA damage.

Urban fine particulate matter causes cardiac hypertrophy through calcium-mediated mitochondrial bioenergetics dysfunction in mice hearts and human cardiomyocytes.

In recent years, the cardiovascular toxicity of urban fine particulate matter (PM) has sparked significant alarm. Mitochondria produce 90% of ATP and make up 30% of the volume of cardiomyocytes. Thus knowledge of myocardial mitochondrial dysfunction due to PM exposure is essential for further cardiotoxic effects.

Research progress of nanoparticle toxicity signaling pathway.

Fast development of nanoscience has drawn increasing attentions and expanded its usage in industry. The research on the toxicity mechanism of nanoparticles is limited comparing to other aspects of study. Oxidative stress and inflammation are publicly known to explain the mechanism of nanoparticles toxicity.