Comprehensive assessment of cascading dams-induced hydrological alterations in the lancang-mekong river using machine learning technique.

The development of cascading hydropower dams in river basins has significantly altered natural flow regimes in recent decades. This study investigates hydrological alterations caused by cascading hydropower dams in the Lancang-Mekong River Basin (LMRB) by integrating the Indicators of Hydrologic Alteration (IHA) method with non-regulated flow predicted using the Random Forest (RF) machine learning (ML) technique. The analysis focuses on four hydrological stations: Chiang Saen, Mukdahan, Pakse, and Stung Treng across pre-impact (1961-1991), transition (1992-2008), and post-impact (2009-2021) periods.

Reconstructing suspended sediment concentrations in the Mekong River Basin via semi-supervised-based deep neural networks.

The Mekong River Basin (MRB) is crucial for the livelihoods of over 60 million people across six Southeast Asian countries. Understanding long-term sediment changes is crucial for management and contingency plans, but the sediment concentration data in the MRB are extremely sporadic, making analysis challenging. This study focuses on reconstructing long-term suspended sediment concentration (SSC) data using a novel semi-supervised machine learning (ML) model.

Recurrence interval of riverbed sand mining hotspots in the Mekong delta: Potential indications of unsustainable replenishment rates.

Rampant and illegal river sand mining in the Vietnamese Mekong Delta (VMD) has led to substantial sediment losses and bank erosion. However, regulation of this issue remains a significant challenge due to insufficient monitoring and enforcement efforts, partly attributed to limited data and technology. To support an improved monitoring system in the VMD, this study investigates the spatiotemporal changes in sand mining hotspots and their underlying drivers.

An assessment of uncontrolled human interventions on the contemporary sediment budget and morphological alterations of the Vu Gia Thu Bon River basin, central Vietnam.

The Vu Gia Thu Bon (VGTB) River basin is critical for regional development and prosperity in water resources. However, human interventions (e.g.

A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.

Protein kinase A (PKA) neuronal function is controlled by the interaction of a regulatory (R) subunit dimer with two catalytic subunits. Recently, the L50R variant in the gene encoding the RIβ subunit was identified in individuals with a novel neurodegenerative disease. However, the mechanisms driving the disease phenotype remained unknown.

StAR-related lipid transfer domain protein 3 (STARD3) regulates HER2 and promotes HER2-positive breast cancer progression through interaction with HSP90 and SRC signaling.

Although various HER2-targeted therapies have been approved clinically, drug resistance remains a considerable challenge. Studies have found that the cause of drug resistance is related to the expression of genes co-amplified with HER2 in breast cancer cells. Our study found that STARD3 was highly expressed in tumor tissues (n = 130, P < 0.

Demographics and Clinical Characteristics of Adult Patients Hospitalized due to COVID-19 in a Rural/Suburban Integrated Health System in Southcentral Pennsylvania, March Through May 2020.

Existing characterizations of coronavirus disease 2019 (COVID-19) admissions have occurred primarily in urban settings. This report describes demographic and clinical characteristics of the first COVID-19 patients presenting to a 6-hospital integrated health care system in rural/suburban southcentral Pennsylvania. Medical records of adult patients admitted with COVID-19 between March and May of 2020 were retrospectively reviewed for demographics, symptomatology, imaging, and lab values.

Intensified salinity intrusion in coastal aquifers due to groundwater overextraction: a case study in the Mekong Delta, Vietnam.

Groundwater salinization is one of the most severe environmental problems in coastal aquifers worldwide, causing exceeding salinity in groundwater supply systems for many purposes. High salinity concentration in groundwater can be detected several kilometers inland and may result in an increased risk for coastal water supply systems and human health problems. This study investigates the impacts of groundwater pumping practices and regional groundwater flow dynamics on groundwater flow and salinity intrusion in the coastal aquifers of the Vietnamese Mekong Delta using the SEAWAT model-a variable-density groundwater flow and solute transport model.

The worst 2020 saline water intrusion disaster of the past century in the Mekong Delta: Impacts, causes, and management implications.

Vietnam Mekong Delta (VMD), the country's most important food basket, is constantly threatened by drought-infused salinity intrusion (SI). The SI disaster of 2020 is recognized as the worst in recent decades, hence inspiring this perspective article. The authors' viewpoints on the disaster's impacts and causes are presented.

The Role of Environmental Factors in the Epidemiology of Infectious Bovine Keratoconjunctivitis.

Environmental factors that contribute to the pathogenesis of infectious bovine keratoconjunctivitis (IBK) include face flies, ultraviolet (UV) radiation, and mechanical irritation from plant awns or dust. Limited research has shown face fly control to be associated with lower incidence of IBK. UV radiation is known to cause corneal irritation and damage in mammalian species.

Intensifying saline water intrusion and drought in the Mekong Delta: From physical evidence to policy outlooks.

This paper assesses the recently intensified saline water intrusion (SI) and drought in the Vietnamese Mekong Delta (VMD). While the existing literature predominantly points the cause of drought to the hydropower dams in the upstream of the Mekong Basin, we contribute new physical evidence of the intensification of saline water intrusion (through backwater effect) in the VMD caused by three anthropogenic drivers: riverbed incision (due to both riverbed mining and dam construction), sea level rise and land subsidence. Thereupon, we highlight that it is critical to not underestimate the impacts from the localized factors, especially the riverbed-mining which can incise the channel by up to 15 cm/year and amplify the salinity intrusion.

Tidal amplification and salt intrusion in the Mekong Delta driven by anthropogenic sediment starvation.

Natural resources of the Mekong River are essential to livelihood of tens of millions of people. Previous studies highlighted that upstream hydro-infrastructure developments impact flow regime, sediment and nutrient transport, bed and bank stability, fish productivity, biodiversity and biology of the basin. Here, we show that tidal amplification and saline water intrusion in the Mekong Delta develop with alarming paces.

Verbal fluency, semantics, context and symptom complexes in schizophrenia.

Lexical-semantic access and retrieval was examined in 15 adults diagnosed with schizophrenia and matched controls. This study extends the literature through the inclusion of multiple examinations of lexical-semantic production within the same patient group and through correlating performance on these tasks with various positive and negative clinical symptoms. On tasks of verbal fluency, meaning generation, sentence production using contextual information and confrontation naming, participants with schizophrenia made significantly more semantic errors on naming tasks; produced fewer meanings for homophones; produced fewer items on semantic, phonological, cued and switching fluency tasks; and produced more errors on sentence production tasks when compared to healthy controls.