Publications by authors named "Bingzhou Xue"
Background: Recent studies have demonstrated that glioma-associated mesenchymal stem cells (GA-MSCs) are implicated in the regulation of glioma malignant progression. However, the prognostic value of GA-MSCs has not been comprehensively explored in glioma.
Methods: We extracted GA-MSCs from glioma tissues, established intracranial xenograft models in nude mice, and obtained GA-MSC-related genes (GA-MSCRGs) by using microarrays.
Background: The tumour microenvironment contributes to chemotherapy resistance in gliomas, and glioma-associated mesenchymal stromal/stem cells (gaMSCs) are important stromal cell components that play multiple roles in tumour progression. However, whether gaMSCs affect chemotherapy resistance to the first-line agent temozolomide (TMZ) remains unclear. Herein, we explored the effect and mechanism of gaMSCs on resistance to TMZ in glioma cells.
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- * It can contribute to tumor heterogeneity, leading to variations in cancer cells that may increase tumor growth, spread, and resistance to treatment.
- * Understanding the mechanisms of cell fusion in tumors could lead to new targeted therapies and innovative approaches for cancer treatment.
Mesenchymal stem cells (MSCs) are important components of stromal cell populations and serve a crucial role in tumor growth and progression. Previously, our laboratory successfully isolated and cultured MSCs from human glioma issues and demonstrated that glioma-associated mesenchymal stem cells (gb-MSCs) participate in and maintain tumor angiogenesis. Furthermore, growth factors, such as fibroblast growth factor and vascular endothelial cell growth factor, were demonstrated to be associated with endothelial cell tube formation.
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- Glioma is a prevalent and aggressive type of brain tumor, leading to a short average survival time of about 15 months even with treatment.
- Research has identified that long non-coding RNAs (lncRNAs) play essential roles in the complex progression of gliomas.
- The review discusses the significance of lncRNAs in glioma development and explores current and future implications for their potential therapeutic applications.
Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90 and CD90 gbMSCs). However, the different roles in glioma progression have not been expounded.
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- Glioma represents over 30% of primary brain tumors, exhibiting symptoms like headaches, epilepsy, and blurred vision, with glioblastoma multiforme being the most aggressive form.
- Despite advances in combination treatments (surgery, radiotherapy, and chemotherapy), the prognosis for glioma patients remains poor, leading to a focus on innovative targeted chemotherapy approaches.
- Mesenchymal stem cell-based therapy, which takes advantage of the tumor-targeting abilities of stem cells, is being researched as a potential treatment for malignant gliomas, though the outcomes of such studies have been complex and challenging.